Dermatology Centre, Salford Royal NHS Foundation Trust, University of Manchester, Manchester, UK;
Clin Med (Lond). 2014 Feb;14(1):47-53. doi: 10.7861/clinmedicine.14-1-47.
This article explores the current and emerging therapies for skin disease, with a particular focus on chronic plaque psoriasis and metastatic malignant melanoma. We discuss the current biological therapies used for psoriasis and those on the horizon, including small molecules and biosimilars. We also summarise the recent advances in the use of novel therapeutic agents in other dermatological diseases and outline the promise of translational research and stratified medicine approaches in dermatology. Better matching of patients with therapies is anticipated to have a major effect on both clinical practice and the development of new drugs and diagnostics.
本文探讨了皮肤病的现有和新兴疗法，特别关注慢性斑块状银屑病和转移性恶性黑色素瘤。我们讨论了目前用于银屑病的生物疗法和即将出现的疗法，包括小分子药物和生物类似药。我们还总结了新型治疗药物在其他皮肤科疾病中的最新应用进展，并概述了转化研究和皮肤科分层医学方法的前景。预计将患者与疗法更好地匹配，将对临床实践以及新药和诊断方法的开发产生重大影响。
