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肝脓肿

Hepatic abscesses.

作者信息

Rajagopalan S, Langer V

机构信息

Professor & HOD, Department of Surgery, AFMC, Pune 411 040, India.

Associate Professor, Department of Surgery, AFMC, Pune 411 040, India.

出版信息

Med J Armed Forces India. 2012 Jul;68(3):271-5. doi: 10.1016/j.mjafi.2012.04.006.

Abstract

Hepatic abscesses are potentially lethal diseases if early diagnosis and treatment are not instituted. They are prevalent all over the globe and pyogenic abscesses are predominant over amoebic. With better control of intra abdominal and systemic infections by a spectrum of antibiotics, aetiology of pyogenic abscesses are secondary to interventions and diseases in the biliary tree to a large extent today. The common organisms isolated are the Gram negative group. Amoebic abscesses continue to plague some regions of the world where hygiene and sanitation are questionable. Over the years, diagnosis, treatment and prognosis have evolved remarkably. Imaging modalities like ultrasonography and CT scan have become the cornerstone of diagnosis. The absence of ionizing radiation makes MRI an attractive alternative in patients who require multiple follow up scans. Serological testing in amoebic abscesses has become more reliable. Though antibiotics have remained the principal modality of management, percutaneous drainage of abscesses have vastly improved the chances of cure and bring down the morbidity drastically in pyogenic abscesses. Amoebic abscesses respond well to medical treatment with nitroimidazoles, and minimally invasive surgical drainage is an option in cases where open surgery is indicated.

摘要

肝脓肿若不及早诊断和治疗,可能会成为致命疾病。肝脓肿在全球范围内普遍存在,其中化脓性脓肿比阿米巴性脓肿更为常见。随着一系列抗生素对腹腔内和全身感染的控制效果越来越好,如今化脓性脓肿的病因在很大程度上继发于胆道树的干预措施和疾病。分离出的常见病原体为革兰氏阴性菌。阿米巴性脓肿继续困扰着世界上一些卫生和环境卫生状况堪忧的地区。多年来,肝脓肿的诊断、治疗和预后有了显著进展。超声检查和CT扫描等影像学检查方法已成为诊断的基石。由于不存在电离辐射,MRI对于需要多次随访扫描的患者来说是一种有吸引力的替代方法。阿米巴性脓肿的血清学检测变得更加可靠。尽管抗生素仍然是主要的治疗方式,但脓肿的经皮引流极大地提高了化脓性脓肿的治愈几率,并大幅降低了发病率。阿米巴性脓肿对硝基咪唑类药物治疗反应良好,在需要进行开放手术的情况下,微创外科引流是一种选择。

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Liver abscess in children: a 10-year single centre experience.儿童肝脓肿:10 年单中心经验。
Saudi J Gastroenterol. 2011 May-Jun;17(3):199-202. doi: 10.4103/1319-3767.80384.
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Pyogenic liver abscess: an audit of 10 years' experience.化脓性肝脓肿:10 年经验的回顾性分析。
World J Gastroenterol. 2011 Mar 28;17(12):1622-30. doi: 10.3748/wjg.v17.i12.1622.
4
Pyogenic liver abscess: Changing patterns in approach.化脓性肝脓肿:治疗方法的变化。
World J Gastrointest Surg. 2010 Dec 27;2(12):395-401. doi: 10.4240/wjgs.v2.i12.395.
5
Liver abscess in children: an overview.儿童肝脓肿:概述。
World J Pediatr. 2010 Aug;6(3):210-6. doi: 10.1007/s12519-010-0220-1. Epub 2010 Aug 13.
8
Non-operative management of pyogenic liver abscess.化脓性肝脓肿的非手术治疗
HPB (Oxford). 2003;5(2):91-5. doi: 10.1080/13651820310001126.
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Pyogenic liver abscess: recent trends in etiology and mortality.化脓性肝脓肿:病因及死亡率的近期趋势
Clin Infect Dis. 2004 Dec 1;39(11):1654-9. doi: 10.1086/425616. Epub 2004 Nov 9.

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