Murphy Andrea Lynn, Gardner David Martin, Kisely Steve, Cooke Charmaine, Kutcher Stanley Paul, Hughes Jean
College of Pharmacy and Department of Psychiatry, Dalhousie University, 5968 College Street, P.O. Box 15000, Halifax, NS, Canada B3H 4R2.
Department of Psychiatry and College of Pharmacy, Dalhousie University, QEII HSC, AJLB 7517, 5909 Veterans' Memorial Lane, Halifax, NS, Canada B3H 2E2.
ISRN Obes. 2013 Nov 20;2013:390130. doi: 10.1155/2013/390130. eCollection 2013.
Objectives. To explore the lived experience of youth, caregivers, and prescribers with antipsychotic medications. Design. We conducted a qualitative interpretive phenomenology study. Youth aged 11 to 25 with recent experience taking antipsychotics, the caregivers of youth taking antipsychotics, and the prescribers of antipsychotics were recruited. Subjects. Eighteen youth, 10 caregivers (parents), and 11 prescribers participated. Results. Eleven of 18 youth, six of ten parents, and all prescribers discussed antipsychotic-related weight gain. Participants were attuned to the numeric weight changes usually measured in pounds. Significant discussions occurred around weight changes in the context of body image, adherence and persistence, managing weight increases, and metabolic effects. These concepts were often inextricably linked but maintained the significance as separate issues. Participants discussed tradeoffs regarding the perceived benefits and risks of weight gain, often with uncertainty and inadequate information regarding the short- and long-term consequences. Conclusion. Antipsychotic-related weight gain in youth influences body image and weight management strategies and impacts treatment courses with respect to adherence and persistence. In our study, the experience of monitoring for weight and metabolic changes was primarily reactive in nature. Participants expressed ambiguity regarding the short- and long-term consequences of weight and metabolic changes.
目标。探讨青少年、照顾者和开抗精神病药物处方者使用抗精神病药物的实际体验。设计。我们进行了一项定性解释现象学研究。招募了近期服用过抗精神病药物的11至25岁青少年、服用抗精神病药物青少年的照顾者以及抗精神病药物的处方者。对象。18名青少年、10名照顾者（父母）和11名处方者参与了研究。结果。18名青少年中的11名、10名父母中的6名以及所有处方者都讨论了与抗精神病药物相关的体重增加问题。参与者关注通常以磅为单位衡量的体重数字变化。围绕身体形象、依从性和持续性、控制体重增加以及代谢影响等方面的体重变化展开了重要讨论。这些概念往往紧密相连，但作为单独的问题仍具有重要意义。参与者讨论了体重增加的感知益处和风险之间的权衡，对于短期和长期后果往往存在不确定性且信息不足。结论。青少年中与抗精神病药物相关的体重增加会影响身体形象和体重管理策略，并在依从性和持续性方面影响治疗过程。在我们的研究中，监测体重和代谢变化的体验本质上主要是被动反应性的。参与者对体重和代谢变化的短期和长期后果表达了模糊态度。
