Blume W T, Lemieux J F
Department of Clinical Neurological Sciences, University of Western Ontario, University Hospital, London, Canada.
Electroencephalogr Clin Neurophysiol. 1988 Jun;69(6):508-15. doi: 10.1016/0013-4694(88)90162-9.
The morphology of spikes of spike-and-wave complexes from 9 patients with primary generalised epilepsy was studied from the scalp recordings of electrodes placed over their fields of maximum expression. Using a 4 x 4 grid electrode placement, selected epochs of the EEG were digitised and stored by a computer program which determined the times of the troughs and peak of the spike as well as its slope, amplitude and duration. Morphological parameters corresponding to those studied for focal spikes in other works gave similar values suggesting a close resemblance between spikes of generalised spike-and-wave complexes and focal spikes. In this study, second half-wave duration exceeded first half-wave duration and amplitudes of the second half-waves were either equal to or greater than those of the first half-waves. Our measures of slope resolved an apparent discrepancy among earlier studies: the entire first half-wave slope was usually equal to or greater than the second half-wave slope while the slopes of the upper half of the spike were usually equal or greater for the second half-wave than for the first. The first half-wave: second half-wave slope ratio was greatest at electrode positions with the maximum spike amplitude (the midline frontal electrodes), and therefore more closely resembled electrocorticogram spikes at these positions.
对9例原发性全身性癫痫患者棘慢复合波的棘波形态进行了研究，电极置于其最大发作区域的头皮记录上。使用4×4网格电极放置法，通过计算机程序对脑电图选定的时间段进行数字化存储，该程序可确定棘波的波谷、峰值时间以及其斜率、幅度和持续时间。与其他研究中针对局灶性棘波所研究的形态学参数得出了相似的值，这表明全身性棘慢复合波的棘波与局灶性棘波非常相似。在本研究中，后半波持续时间超过前半波持续时间，后半波的幅度等于或大于前半波。我们的斜率测量解决了早期研究中一个明显的差异：整个前半波斜率通常等于或大于后半波斜率，而棘波上半部分的斜率后半波通常比前半波相等或更大。前半波与后半波斜率之比在棘波幅度最大的电极位置（中线额电极）最大，因此在这些位置更类似于皮质电图棘波。
