Verhoeven V M
Clinique Psychiatrique Universitaire, Service de Psychiatrie Biologique, Utrecht, (Pays-Bas).
Encephale. 1987 Nov-Dec;13(6):349-56.
Recently much interest has been shown in the antipsychotic efficacy of neuroleptic-like neuropeptides in schizophrenia. In this article the clinical effects of the non-opioid fragments of gamma-endorphin, the so-called gamma-type endorphins DT gamma E and DE gamma E are reviewed. In addition, preliminary clinical studies of peptides related to cholecystokinin are considered. It is concluded that gamma-type endorphins possess antipsychotic properties in a subgroup of patients who may belong to Type I schizophrenia. With cholecystokinin-related peptides, in particular ceruletide, antipsychotic effects have been reported, which seem to be more or less comparable to those observed with gamma-type endorphins.
最近，人们对精神分裂症中类神经阻滞剂神经肽的抗精神病疗效表现出了浓厚兴趣。本文综述了γ-内啡肽的非阿片样片段（即所谓的γ型内啡肽DTγE和DEγE）的临床效果。此外，还考虑了与胆囊收缩素相关肽的初步临床研究。结论是，γ型内啡肽在可能属于Ⅰ型精神分裂症的亚组患者中具有抗精神病特性。对于与胆囊收缩素相关的肽，特别是雨蛙肽，已经报道了其抗精神病作用，这些作用似乎与γ型内啡肽所观察到的作用大致相当。
