Center for Reproductive Medicine, Dutch-Speaking Free University Brussels, Brussels, Belgium.
Special Gynecology Hospital "Ivanovic", Belgrade, Serbia.
Fertil Steril. 2014 Apr;101(4):1008-11. doi: 10.1016/j.fertnstert.2014.01.019. Epub 2014 Feb 15.
To report two cases with GnRH agonist triggering and a freeze-all approach in a GnRH antagonist protocol resulting in the development of severe ovarian hyperstimulation syndrome (OHSS), requiring hospitalization and peritoneal drainage.
Two case reports.
A tertiary referral center and an obstetrics and gynecology department of a hospital.
PATIENT(S): Case 1 and case 2: severe OHSS with abdominal distension, ascites development, and hemoconcentration.
INTERVENTION(S): Case 1 and case 2: diagnosed by clinical, hematologic, and ultrasound findings. Hospitalization, IV infusion, and peritoneal drainage.
MAIN OUTCOME MEASURE(S): Symptomatic treatment and prevention of further complication.
RESULT(S): Complete recovery.
CONCLUSION(S): Two cases of severe OHSS after GnRH agonist trigger in a GnRH antagonist protocol without the administration of any hCG for luteal-phase support. Clinicians have to be aware that even the sequential approach to ovarian stimulation with a freeze-all attitude does not completely eliminate OHSS in all patients.
报告两例在 GnRH 拮抗剂方案中使用 GnRH 激动剂触发和全冷冻方法导致严重卵巢过度刺激综合征（OHSS）发展的病例，需要住院和腹腔引流。
两例病例报告。
一家三级转诊中心和一家医院的妇产科。
病例 1 和病例 2：严重 OHSS 伴有腹胀、腹水形成和血液浓缩。
病例 1 和病例 2：根据临床、血液学和超声检查结果诊断。住院、静脉输液和腹腔引流。
症状治疗和预防进一步并发症。
完全恢复。
在 GnRH 拮抗剂方案中使用 GnRH 激动剂触发而没有任何 hCG 进行黄体期支持后，两例出现严重 OHSS。临床医生必须意识到，即使采用序贯卵巢刺激方法并采取全冷冻态度，也不能完全消除所有患者的 OHSS。
