Bordi C, Pilato F P, Bertelé A, D'Adda T, Missale G
Institute of Anatomic Pathology, University of Parma, Italy.
Hum Pathol. 1988 May;19(5):580-5. doi: 10.1016/s0046-8177(88)80208-9.
Previous studies have shown that hyperplastic endocrine cells of the oxyntic mucosa in patients with atrophic gastritis may express immunoreactivity for the alpha-subunit of human chorionic gonadotropin (alpha-HCG, common to all glycoprotein hormones). Since this endocrine proliferation is regarded as dependent on the trophic effect of the concomitant hypergastrinemia, the relation between immunohistochemical expression of alpha-HCG by oxyntic endocrine cells and serum levels of gastrin were investigated. The study was performed on endoscopic gastric biopsies of the oxyntic mucosa from 49 patients subdivided into the following groups: A) with histologically normal mucosa and normogastrinemia (22 cases), B) with atrophic gastritis and normogastrinemia (12 cases), C) with normal mucosa and hypergastrinemia (Zollinger-Ellison syndrome, retained antrum) (7 cases) and D) with atrophic gastritis and hypergastrinemia (with or without pernicious anemia) (8 cases). The alpha-HCG immunoreactive cells were found in all hypergastrinemic patients (groups C and D), regardless of the concomitant pathological condition of the mucosa. These cells accounted for 7.8% to 44.7% of the number of Grimelius argyrophil cells in consecutive serial sections. In contrast, alpha-HCG-containing cells were exceptional or absent in most normogastrinemic patients. Their number was sizable in only two cases of group A and three cases of group B, where it ranged from 2.5% to 14.8% of the number of argyrophil cells. It was concluded that expression of alpha-HCG is another feature of oxyntic endocrine cells associated with hypergastrinemia in addition to those previously recognized such as development of hyperplasia and/or carcinoid tumors.
既往研究表明，萎缩性胃炎患者胃体黏膜的增生性内分泌细胞可能表达人绒毛膜促性腺激素α亚基（α-HCG，所有糖蛋白激素所共有）的免疫反应性。由于这种内分泌细胞增生被认为依赖于伴随的高胃泌素血症的营养作用，因此研究了胃体内分泌细胞α-HCG的免疫组化表达与胃泌素血清水平之间的关系。该研究对49例患者的胃体黏膜内镜活检标本进行，这些患者被分为以下几组：A组）组织学上黏膜正常且胃泌素水平正常（22例），B组）萎缩性胃炎且胃泌素水平正常（12例），C组）黏膜正常且胃泌素水平升高（佐林格-埃利森综合征、胃窦保留）（7例），D组）萎缩性胃炎且胃泌素水平升高（伴或不伴有恶性贫血）（8例）。在所有高胃泌素血症患者（C组和D组）中均发现了α-HCG免疫反应性细胞，无论黏膜的伴随病理状况如何。在连续系列切片中，这些细胞占嗜银细胞数量的7.8%至44.7%。相比之下，大多数胃泌素水平正常的患者中，含α-HCG的细胞罕见或不存在。仅在A组的2例和B组的3例中，其数量可观，占嗜银细胞数量的2.5%至14.8%。研究得出结论，α-HCG的表达是胃体内分泌细胞与高胃泌素血症相关的另一个特征，除此之外还有先前已认识到的如增生和/或类癌肿瘤的发生等特征。
