非编码 RNA 对染色质修饰复合物的转调控作用。
Modulation of chromatin modifying complexes by noncoding RNAs in trans.
机构信息
Laboratory of Cellular and Developmental Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
Laboratory of Cellular and Developmental Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
出版信息
Curr Opin Genet Dev. 2014 Apr;25:68-73. doi: 10.1016/j.gde.2013.11.019. Epub 2014 Feb 15.
Increasing evidence supports a central role for ncRNA in numerous aspects of chromatin function. For instance, ncRNAs can act as a scaffold for the recruitment of certain chromatin modifying complexes to specific sites within the genome. It is easily imaginable how this can occur in cis, but examples also exist whereby targeting of complexes by ncRNA occurs in trans to the site of transcription. Moreover, association of an ncRNA with a particular locus can trigger localization of the gene to a subnuclear structure harboring a specialized transcriptional environment. In this review, we discuss new insights into the mechanisms by which ncRNAs function in trans with respect to Polycomb Group, chromatin insulator, and dosage compensation complexes in mammals and/or Drosophila.
越来越多的证据表明，非编码 RNA 在染色质功能的许多方面都起着核心作用。例如，ncRNA 可以作为某些染色质修饰复合物在基因组特定位置募集的支架。这种情况在顺式中很容易发生，但也有例子表明，ncRNA 通过反式靶向复合物发生作用。此外，ncRNA 与特定基因座的结合可以触发该基因定位到含有专门转录环境的亚核结构。在这篇综述中，我们讨论了 ncRNA 在哺乳动物和/或果蝇的多梳组、染色质绝缘子和剂量补偿复合物中发挥反式作用的机制的新见解。
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