Tao Hui, Yang Jing-Jing, Hu Wei, Shi Kai-Hu, Deng Zi-Yu, Li Jun
Department of Cardiothoracic Surgery, The Second Hospital of Anhui Medical University, Hefei, 230601, China.
Cardiovascular Research Center, Anhui Medical University, Hefei, 230601, China.
Pflugers Arch. 2016 Jun;468(6):1103-11. doi: 10.1007/s00424-016-1792-y. Epub 2016 Jan 20.
Cardiac fibrosis is an important pathological feature of cardiac remodeling in heart diseases. The molecular mechanisms of cardiac fibrosis are unknown. Genomic analyses estimated that many noncoding DNA regions generate noncoding RNAs (ncRNAs). ncRNAs have emerged as key molecular players in the regulation of gene expression in different biological processes. Recent studies have started to reveal the importance of ncRNAs in heart development and suggest also an involvement in cardiac fibrosis. These molecules are emerging as important regulators of cellular process. Here, we review particularly focuses on the involvement of two large families of ncRNAs, namely microRNAs (miRNAs) and long noncoding RNAs (LncRNAs) in the regulation of cardiac fibrosis. Furthermore, we review the functions and role of ncRNAs in cardiac biology and discuss these reports and the therapeutic potential of ncRNAs for cardiac fibrosis associated with fibroblast activation and proliferation.
心脏纤维化是心脏疾病中心脏重塑的一个重要病理特征。心脏纤维化的分子机制尚不清楚。基因组分析估计，许多非编码DNA区域可产生非编码RNA（ncRNA）。ncRNA已成为不同生物学过程中基因表达调控的关键分子参与者。最近的研究开始揭示ncRNA在心脏发育中的重要性，并表明其也参与心脏纤维化。这些分子正成为细胞过程的重要调节因子。在此，我们的综述特别关注两类大型ncRNA，即微小RNA（miRNA）和长链非编码RNA（LncRNA）在心脏纤维化调控中的作用。此外，我们综述了ncRNA在心脏生物学中的功能和作用，并讨论了这些报道以及ncRNA针对与成纤维细胞激活和增殖相关的心脏纤维化的治疗潜力。
