• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

A specific nucleotide sequence defines a functional T-cell recognition epitope shared by diverse HLA-DR specificities.

作者信息

Seyfried C E, Mickelson E, Hansen J A, Nepom G T

机构信息

Virginia Mason Research Center, Seattle, WA 98101.

出版信息

Hum Immunol. 1988 Apr;21(4):289-99. doi: 10.1016/0198-8859(88)90037-7.

DOI:10.1016/0198-8859(88)90037-7
PMID:2453493
Abstract

An oligonucleotide probe that distinguishes the HLA-DR4, Dw14 allele from other HLA-DR4-associated class II genes was used to identify a common nucleotide sequence shared between the DR beta 1 locus encoding HLA-DR1 (Dw1), Dw16, and DRw10 haplotypes. The presence of this nucleotide sequence correlated with the ability of these haplotypes to stimulate an alloreactive proliferative T-cell clone (clone 14B) raised against a Dw14+ stimulator cell. Alleles of DR beta 1 that differ by one specific nucleotide variation at codon 71 neither hybridize to the Dw14-specific oligonucleotide nor stimulate clone 14B. These data demonstrate the presence of a shared epitope present on serologically distinct DR alleles that is recognized as a specific allodeterminant by a single T-cell clone.

摘要

相似文献

1
A specific nucleotide sequence defines a functional T-cell recognition epitope shared by diverse HLA-DR specificities.
Hum Immunol. 1988 Apr;21(4):289-99. doi: 10.1016/0198-8859(88)90037-7.
2
Nonrandom selection of T cell specificities in anti-HLA-DR responses. Sequence motifs of the responder HLA-DR allele influence T cell recruitment.抗HLA-DR应答中T细胞特异性的非随机选择。应答者HLA-DR等位基因的序列基序影响T细胞募集。
J Immunol. 1991 Jul 1;147(1):70-8.
3
T-cell clones identify three distinct epitopes associated with HLA-Dw14.T细胞克隆鉴定出与HLA-Dw14相关的三个不同表位。
Hum Immunol. 1991 Nov;32(3):229-33. doi: 10.1016/0198-8859(91)90060-m.
4
HLA-Dw14 and HLA-DR3 haplotypes share a functional determinant recognized by a human alloreactive T-cell clone.HLA - Dw14和HLA - DR3单倍型共享一个可被人同种异体反应性T细胞克隆识别的功能决定簇。
Hum Immunol. 1988 Sep;23(1):59-70. doi: 10.1016/0198-8859(88)90018-3.
5
Nucleotide sequence of a DRw10 beta chain cDNA clone. Identity of the third D region with that of the DRw53 allele of the beta 2 locus and as the probable site encoding a polymorphic MHC class II epitope.DRw10 β链cDNA克隆的核苷酸序列。β2基因座的第三个D区域与DRw53等位基因的第三个D区域相同，且可能是编码多态性MHC II类表位的位点。
J Immunol. 1988 Apr 1;140(7):2447-52.
6
Functional polymorphism of each of the two HLA-DR beta chain loci demonstrated with antigen-specific DR3- and DRw52-restricted T cell clones.利用抗原特异性DR3和DRw52限制性T细胞克隆证明了两个HLA - DRβ链基因座各自的功能多态性。
J Exp Med. 1988 Mar 1;167(3):853-72. doi: 10.1084/jem.167.3.853.
7
Functional polymorphism of the HLA-DR beta III chain.
Hum Immunol. 1988 Jan;21(1):49-61. doi: 10.1016/0198-8859(88)90080-8.
8
Effect of natural polymorphism at residue 86 of the HLA-DR beta chain on peptide binding.HLA-DRβ链第86位残基自然多态性对肽结合的影响。
J Immunol. 1991 Aug 15;147(4):1292-8.
9
Clonal analysis of HLA-DR and -DQ associated determinants: their contribution to Dw specificities.HLA-DR和-DQ相关决定簇的克隆分析：它们对Dw特异性的贡献。
Hum Immunol. 1986 Aug;16(4):329-46. doi: 10.1016/0198-8859(86)90060-1.
10
An antiviral T-cell clone defines a functional supertypic specificity shared by different HLA-DR molecules from DR2-short, DRw11, and DRw13 haplotypes.一个抗病毒T细胞克隆定义了一种功能超型特异性，该特异性由来自DR2短单倍型、DRw11和DRw13单倍型的不同HLA-DR分子共享。
Immunogenetics. 1987;25(2):84-90. doi: 10.1007/BF00364272.

引用本文的文献

1
Genetic background and environment contribute synergistically to the onset of autoimmune diseases.遗传背景和环境对自身免疫性疾病的发病起协同作用。
J Mol Med (Berl). 1995 Aug;73(8):381-93. doi: 10.1007/BF00240137.
2
Structural variation among major histocompatibility complex class-II genes which predispose to autoimmunity.主要组织相容性复合体II类基因中的结构变异易引发自身免疫。
Immunol Res. 1989;8(1):16-38. doi: 10.1007/BF02918553.
3
Epstein-Barr virus and rheumatoid arthritis: cellular and molecular aspects.
Rheumatol Int. 1989;9(3-5):147-52. doi: 10.1007/BF00271872.
4
Susceptibility to rheumatoid arthritis maps to a T-cell epitope shared by the HLA-Dw4 DR beta-1 chain and the Epstein-Barr virus glycoprotein gp110.类风湿关节炎易感性定位到HLA-Dw4 DRβ-1链与爱泼斯坦-巴尔病毒糖蛋白gp110共有的一个T细胞表位。
Proc Natl Acad Sci U S A. 1989 Jul;86(13):5104-8. doi: 10.1073/pnas.86.13.5104.
5
HLA-DR1 and DRw6 association in DR4-negative rheumatoid arthritis patients.HLA-DR1与DRw6在DR4阴性类风湿关节炎患者中的关联。
Rheumatol Int. 1990;10(4):171-5. doi: 10.1007/BF02274843.
6
Molecular basis of human leukocyte antigen class II disease associations.人类白细胞抗原II类疾病关联的分子基础。
Adv Immunol. 1990;48:107-59. doi: 10.1016/s0065-2776(08)60753-1.
7
Unique sequences for two HLA-DRB1 genes expressed on distinct DRw6 haplotypes.在不同的DRw6单倍型上表达的两个HLA - DRB1基因的独特序列。
Immunogenetics. 1990;32(2):96-103. doi: 10.1007/BF00210446.
8
Structural requirements for recognition of the HLA-Dw14 class II epitope: a key HLA determinant associated with rheumatoid arthritis.HLA-Dw14 Ⅱ类表位识别的结构要求：与类风湿性关节炎相关的关键HLA决定簇
Proc Natl Acad Sci U S A. 1990 Oct;87(20):8051-5. doi: 10.1073/pnas.87.20.8051.
9
HLA-DR antigen linkage of anti-beta receptor antibodies in idiopathic dilated and ischaemic cardiomyopathy.特发性扩张型和缺血性心肌病中抗β受体抗体与HLA - DR抗原的关联
Br Heart J. 1992 May;67(5):402-5. doi: 10.1136/hrt.67.5.402.