Chang Sung Soo, Yokomise Hiroyasu, Matsuura Natsumi, Gotoh Masashi, Tabata Yasuhiko
Department of General Thoracic, Breast, and Endocrinological Surgery, Faculty of Medicine, Kagawa University, 1750-1 Ikenobe, Miki-cho, Kita-gun, Kagawa, 761-0793, Japan.
Surg Today. 2014 Aug;44(8):1536-41. doi: 10.1007/s00595-014-0864-x. Epub 2014 Feb 18.
The prognosis of patients with emphysema is poor as there is no truly effective treatment. Our previous study showed that the alveolar space was smaller and the microvessel density was higher in a canine emphysema model after the intrapulmonary arterial administration of gelatin microspheres slowly releasing basic fibroblast growth factor (bFGF-GMS). In the present study, we evaluated the functional effect of injecting bFGF-GMS via the pulmonary artery in this canine pulmonary emphysema model.
Using the porcine pancreatic elastase (PPE)-induced total emphysema model, we approximated the value of lung compliance with a Power Lab System, and performed blood gas analysis in a control group, a total emphysema group, and a bFGF group in which bFGF-GMS were injected toward the whole pulmonary artery via the femoral vein. Each group comprised five dogs.
Lung compliance was higher in the total emphysema group than in the control group (p = 0.031), and the bFGF group showed no significant improvement of lung compliance vs. the total emphysema group (p = 0.112). PaO2 (partial pressure of oxygen in arterial blood) was improved by administering bFGF-GMS in the total emphysema model (p = 0.027).
In the canine total emphysema model, blood gas parameters were improved by the whole pulmonary arterial administration of bFGF-GMS. This method has the potential to be an effective novel therapy for pulmonary emphysema.
由于没有真正有效的治疗方法，肺气肿患者的预后较差。我们之前的研究表明，在肺动脉内注射缓慢释放碱性成纤维细胞生长因子的明胶微球（bFGF-GMS）后，犬肺气肿模型的肺泡腔较小，微血管密度较高。在本研究中，我们评估了在该犬肺气肿模型中经肺动脉注射bFGF-GMS的功能效果。
使用猪胰弹性蛋白酶（PPE）诱导的全肺气肿模型，我们用Power Lab系统估算肺顺应性的值，并在对照组、全肺气肿组和通过股静脉向整个肺动脉注射bFGF-GMS的bFGF组中进行血气分析。每组包括五只狗。
全肺气肿组的肺顺应性高于对照组（p = 0.031），与全肺气肿组相比，bFGF组的肺顺应性无显著改善（p = 0.112）。在全肺气肿模型中，通过给予bFGF-GMS可改善动脉血氧分压（PaO2）（p = 0.027）。
在犬全肺气肿模型中，经全肺动脉给予bFGF-GMS可改善血气参数。该方法有可能成为一种有效的肺气肿新疗法。
