Experimental Station, DuPont Central Research and Development, Wilmington, DE, USA.
Magn Reson Chem. 2014 Apr;52(4):183-9. doi: 10.1002/mrc.4052. Epub 2014 Feb 17.
The effectiveness of hetero-COSY, HETCOR, HMQC, and HSQC two-dimensional NMR pulse sequences for detection of (19)F-(1)H correlations by scalar coupling was evaluated on monofluorinated and polyfluorinated test compounds. All four of these sequences were effective in observing (1)H-(19)F correlations, using either (19) F or (1)H as the observe nucleus. All four sequences were amenable, to some degree, to adjustment to observe larger or smaller couplings preferentially. A 1/2J echo filter was effectively applied to remove artifacts from (2)JFF strong coupling. The HETCOR experiments afforded the best overall combination of sensitivity, resolution and selectivity for JHF.
对异核 COSY、HETCOR、HMQC 和 HSQC 二维 NMR 脉冲序列通过标量耦合检测（19）F-（1）H 相关性的有效性在单氟代和多氟代测试化合物上进行了评估。这四个序列都可以有效地观察到（1）H-（19）F 相关性，无论是使用（19）F 还是（1）H 作为观测核。这四个序列在一定程度上都可以进行调整，以优先观察更大或更小的耦合。1/2J 回波滤波器有效地应用于从 2JFF 强耦合中去除伪影。对于 JHF，HETCOR 实验提供了最佳的灵敏度、分辨率和选择性的综合组合。
