环孢素A抑制人肺肥大细胞释放组胺和白三烯C4肽。

Cyclosporin A inhibits the release of histamine and peptide leukotriene C4 from human lung mast cells.

作者信息

Marone G, Triggiani M, Cirillo R, Giacummo A, Siri L, Condorelli M

机构信息

I Clinica Medica, II Facoltà di Medicina e Chirurgia, Università degli Studi di Napoli.

出版信息

Ric Clin Lab. 1988 Jan-Mar;18(1):53-9. doi: 10.1007/BF02918819.

DOI:10.1007/BF02918819

PMID:2453912

Abstract

We investigated the effect of cyclosporin A (CsA) on in vitro release of chemical mediators from mast cells purified from human lung tissues. CsA (3 X 10(-2) to 1 microgram/ml) dose-dependently inhibited IgE-mediated release of histamine and peptide leukotriene C4 (LTC4) from human lung mast cells. The same concentrations of CsA also inhibited the release of histamine from lung mast cells challenged with the Ca2+ ionophore A23187. Therefore, CsA in pharmacological concentrations inhibits the IgE- and non-IgE-mediated release of inflammatory mediators from mast cells purified from human lung tissues.

摘要

我们研究了环孢素A（CsA）对从人肺组织中纯化的肥大细胞体外释放化学介质的影响。CsA（3×10⁻²至1微克/毫升）剂量依赖性地抑制人肺肥大细胞中IgE介导的组胺和肽白三烯C4（LTC4）的释放。相同浓度的CsA也抑制用Ca²⁺离子载体A23187刺激的肺肥大细胞中组胺的释放。因此，药理浓度的CsA抑制从人肺组织中纯化的肥大细胞释放IgE介导和非IgE介导的炎症介质。