Goadsby P J, Edvinsson L, Ekman R
Department of Neurology, Prince Henry Hospital, Little Bay, N. S. W., Australia.
Ann Neurol. 1988 Feb;23(2):193-6. doi: 10.1002/ana.410230214.
The trigeminal ganglion was activated, in humans by thermocoagulation as part of the treatment of trigeminal neuralgia and in cats by electrical stimulation, and blood samples were taken from the external jugular vein for estimates of plasma levels of substance P and calcitonin gene-related peptide (CGRP). In those patients who were noted at the time of coagulation to have flushed there were marked elevations of the local (cranial) levels of both peptides. However, in the nonflushing patients no changes in the peptide levels were observed. Parallel experiments in the cat revealed that the levels of substance P-like and CGRP-like immunoreactivity were increased during electrical stimulation of the trigeminal ganglion. The observation of elevation of substance P-like and CGRP-like immunoreactivity after activation of the nociceptive afferent system of the head provides new insights into a putative role of peptides in the pathophysiology of migraine and cluster headache, and suggests new areas of possible therapeutic intervention.
三叉神经节被激活，在人类中是通过热凝作为三叉神经痛治疗的一部分，在猫中是通过电刺激，并且从颈外静脉采集血样以估计血浆中P物质和降钙素基因相关肽（CGRP）的水平。在那些在热凝时被观察到面部潮红的患者中，两种肽的局部（颅内）水平显著升高。然而，在无面部潮红的患者中，未观察到肽水平的变化。在猫身上进行的平行实验表明，在电刺激三叉神经节期间，P物质样和CGRP样免疫反应性水平升高。头部伤害性传入系统激活后P物质样和CGRP样免疫反应性升高的观察结果为肽在偏头痛和丛集性头痛病理生理学中的假定作用提供了新的见解，并提示了可能的治疗干预新领域。
