Chang H T
Department of Anatomy and Neurobiology, University of Tennessee, Memphis, College of Medicine 38163.
Brain Res. 1988 May 17;448(2):391-6. doi: 10.1016/0006-8993(88)91284-x.
The synaptic relationships between substance P-containing terminals and dopaminergic neurons (immunoreactive for tyrosine hydroxylase) in the substantia nigra were studied at both light and electron microscopic levels using a pre-embedding double-labeling immunocytochemical method. Many substance P-containing terminals were found to form synapses directly with dendrites and somata of nigral dopaminergic neurons. Since most of the substance P-containing axon terminals arise from the striatum, this result suggests that striatal substance P neurons can have monosynaptic influence on nigral dopaminergic neurons.
采用包埋前双重标记免疫细胞化学方法，在光学显微镜和电子显微镜水平上研究了黑质中含P物质的终末与多巴胺能神经元（酪氨酸羟化酶免疫反应阳性）之间的突触关系。发现许多含P物质的终末直接与黑质多巴胺能神经元的树突和胞体形成突触。由于大多数含P物质的轴突终末起源于纹状体，这一结果表明纹状体含P物质的神经元可能对黑质多巴胺能神经元有单突触影响。
