Dibble J B, Kalra P A, Orchard M A, Turney J H, Davies J A
Renal Unit, General Infirmary, Leeds, UK.
Thromb Res. 1988 Feb 15;49(4):385-92. doi: 10.1016/0049-3848(88)90241-1.
The actions of prostacyclin and iloprost, as supplements to heparin therapy, were examined by measuring indices of blood coagulation and platelet activation during the first two hours of haemodialysis in six patients with stable chronic renal failure. Patients received either prostacyclin 5 ng kg-1 min-1, iloprost 2 ng kg-1 min-1 or placebo at random on three separate occasions as a supplement to standard therapy with heparin 50 I.U. kg-1 loading dose and 30 I.U. kg-1 hr-1 infusion. Neither prostacyclin nor iloprost significantly affected dialysis induced changes in whole blood platelet count and plasma concentrations of beta thromboglobulin, (beta TG) platelet factor 4 (PF4), fibrinogen and fibrinopeptide A. Thus platelet count still fell by 12 +/- 8% within 15 min of the start of dialysis, slowly returning to the initial count over the study period and plasma PF4 increased nearly 10 fold over the same time. In addition, serial measurements of KCCT failed to indicate any sparing effect of the prostanoids on this dose of heparin.
在6例稳定的慢性肾衰竭患者进行血液透析的前两小时内，通过测量血液凝固指标和血小板活化指标，研究了前列环素和依洛前列素作为肝素治疗补充剂的作用。患者在三个不同的时间段随机接受前列环素5 ng·kg⁻¹·min⁻¹、依洛前列素2 ng·kg⁻¹·min⁻¹或安慰剂，作为肝素50 I.U.·kg⁻¹负荷剂量和30 I.U.·kg⁻¹·hr⁻¹输注的标准治疗的补充。前列环素和依洛前列素均未显著影响透析引起的全血血小板计数以及血浆β-血小板球蛋白（β-TG）、血小板因子4（PF4）、纤维蛋白原和纤维蛋白肽A浓度的变化。因此，透析开始后15分钟内血小板计数仍下降12±8%，在研究期间缓慢恢复到初始计数，同时血浆PF4在同一时间内增加近10倍。此外，KCCT的系列测量未能表明前列腺素对该剂量肝素具有任何节省作用。
