Goodlad R A, Wilson T J, Lenton W, Gregory H, McCullagh K G, Wright N A
Z Gastroenterol Verh. 1988 Apr;23:171-7.
Recombinant urogastrone (human epidermal growth factor) was infused into rats in which intestinal cell proliferation was reduced to a steady state basal level by feeding them intravenously. Urogastrone elevated the augmented metaphase index and weight of all sections of the gastrointestinal tract in a dose-related manner. Infusion of urogastrone at a dose which has a minimal effect on gastric acid secretion significantly increased crypt cell production and tissue weights throughout the gastrointestinal tract. Intravenous urogastrone was also effective in restoring cell proliferation after the intestine had become hypoproliferative. Urogastrone administered luminally had no significant effect on either intestinal weight, crypt cell production rate, or metaphase collection.
将重组urogastrone（人表皮生长因子）注入大鼠体内，这些大鼠通过静脉喂食使肠道细胞增殖降至稳定的基础水平。urogastrone以剂量相关的方式提高了胃肠道各节段的中期指数和重量。以对胃酸分泌影响最小的剂量注入urogastrone，可显著增加整个胃肠道的隐窝细胞生成和组织重量。在肠道增殖不足后，静脉注射urogastrone在恢复细胞增殖方面也有效。腔内给予urogastrone对肠道重量、隐窝细胞生成率或中期收集均无显著影响。
