尿抑胃素-表皮生长因子对经肠道外喂养的大鼠的肠上皮具有营养作用。
Urogastrone-epidermal growth factor is trophic to the intestinal epithelium of parenterally fed rats.
作者信息
Goodlad R A, Wilson T J, Lenton W, Gregory H, McCullough K G, Wright N A
出版信息
Experientia. 1985 Sep 15;41(9):1161-3. doi: 10.1007/BF01951708.
PMID:3930283
Abstract
The weight of the stomach, small intestine and colon and the mucosal crypt cell production rate of these tissues were significantly decreased after 10 days on an isocaloric TPN diet when compared to orally fed controls. Continuous infusion of recombinant beta urogastrone, at a dose below that needed to inhibit gastric acid secretion, largely prevented this decrease in crypt cell production rate and gastrointestinal tissue weights.
摘要
与经口喂养的对照组相比，等热量全胃肠外营养（TPN）饮食10天后，胃、小肠和结肠的重量以及这些组织的黏膜隐窝细胞产生率显著降低。以低于抑制胃酸分泌所需的剂量持续输注重组β-尿抑胃素，在很大程度上可防止隐窝细胞产生率和胃肠道组织重量的这种降低。
Zotero 插件