Department of Epidemiology and Biostatistics, Faculty of Health, Zabol University of Medical Sciences, Zabol, Iran.
Department of Epidemiology and Biostatistics, Faculty of Health, Zabol University of Medical Sciences, Zabol, Iran.
Obes Res Clin Pract. 2014 Jan-Feb;8(1):e26-34. doi: 10.1016/j.orcp.2012.07.004.
The aim of this study was to investigate erythrocyte antioxidant enzyme activities in general and abdominal obese women.
In this study, 160 women 20-45 years old were randomly selected. General information data were gathered from each sample using questionnaires and face-to-face interviews. Activities of erythrocyte antioxidant enzymes were also evaluated by measuring activities of copper zinc-superoxide dismutase (CuZn-SOD), glutathione peroxidase (GSH-Px) and catalase (CAT) in selected subjects.
Mean activity of CuZn-SOD was significantly lower in overweight and obese groups compared to normal weight group (721 ± 81 vs. 987 ± 84, p < 0.01 and 638 ± 74 vs. 987 ± 84, p < 0.001, respectively). Furthermore, both erythrocyte GSH-Px (97.6 ± 45.2 vs. 148.7 ± 54.2, p < 0.01) and CAT (184.2 ± 37.8 vs. 316.7 ± 65.8, p < 0.01) activities was significantly lower in obese women compared to normal weight women. In addition, women with abdominal obesity had lower erythrocyte CuZn-SOD (632 ± 76 vs. 871 ± 84, p < 0.001), GSH-Px (103.6 ± 52.8 vs. 154.7 ± 62.4, p < 0.01) and CAT (216.6 ± 76.4 vs. 298.3 ± 71.1, p < 0.05) activities compared to women with normal body fat distribution. Moreover, multiple linear regression analysis suggests higher prediction of waist circumference (i.e. higher R(2)) on antioxidant enzyme activities in relation to other adiposity indicators.
Our results provides further evidence suggesting that obesity and, especially, abdominal adiposity associated with decreased antioxidant enzyme activities which in turn, may contribute to oxidative stress related to obesity.
本研究旨在探讨红细胞抗氧化酶活性与一般和腹部肥胖女性之间的关系。
本研究随机选取了 160 名 20-45 岁的女性。通过问卷和面对面访谈收集每个样本的一般信息数据。还通过测量选定对象的铜锌-超氧化物歧化酶（CuZn-SOD）、谷胱甘肽过氧化物酶（GSH-Px）和过氧化氢酶（CAT）的活性来评估红细胞抗氧化酶的活性。
与正常体重组相比，超重和肥胖组的 CuZn-SOD 活性显著降低（721±81 与 987±84，p<0.01 和 638±74 与 987±84，p<0.001）。此外，肥胖女性的红细胞 GSH-Px（97.6±45.2 与 148.7±54.2，p<0.01）和 CAT（184.2±37.8 与 316.7±65.8，p<0.01）活性也明显低于正常体重女性。此外，与正常体脂分布的女性相比，腹部肥胖的女性的红细胞 CuZn-SOD（632±76 与 871±84，p<0.001）、GSH-Px（103.6±52.8 与 154.7±62.4，p<0.01）和 CAT（216.6±76.4 与 298.3±71.1，p<0.05）活性均较低。此外，多元线性回归分析表明，腰围（即较高的 R²）对抗氧化酶活性的预测更高，而腰围与其他肥胖指标的相关性更高。
我们的结果进一步表明，肥胖，尤其是腹部肥胖与抗氧化酶活性降低有关，而抗氧化酶活性降低可能与肥胖相关的氧化应激有关。
