通过评估丘脑底核深部脑刺激和左旋多巴的效果来验证用于帕金森病的GDI、GPS和GVS。
Validation of GDI, GPS and GVS for use in Parkinson's disease through evaluation of effects of subthalamic deep brain stimulation and levodopa.
作者信息
Speciali Danielli Souza, Corrêa João Carlos Ferrari, Luna Natália Mariana, Brant Rachael, Greve Julia Maria D'Andrea, de Godoy Wagner, Baker Richard, Lucareli Paulo Roberto Garcia
机构信息
Department of Rehabilitation Science, Human Motion Analysis Laboratory, Universidade Nove de Julho, São Paulo, Brazil.
Department of Orthopaedics and Traumatology, Universidade de São Paulo, São Paulo, Brazil.
出版信息
Gait Posture. 2014 Apr;39(4):1142-5. doi: 10.1016/j.gaitpost.2014.01.011. Epub 2014 Jan 30.
The Gait Deviation Index (GDI), Gait Profile Score (GPS) and Gait Variable Scores (GVSs) have been proposed as measures of gait quality and validated for use with children with cerebral palsy. The aim of this study was to extend this validation to people with Parkinson's disease by evaluating the effects of subthalamic deep brain stimulation and levodopa on gait. 16 participants had their gait evaluated with stimulation, medication or a combination of both. The Unified Parkinson's Disease Rating Scale (UPDRS) showed statistically significant differences in agreement with previous studies. The GPS and GDI showed similar treatment effects as did GVS for hip and knee flexion/extension, as assessed with Cohen's d where medium or large. Overall the results suggest that these gait indices are sensitive to treatment in this group of patients and that their use in groups other than children with cerebral palsy is valid.
步态偏差指数（GDI）、步态轮廓评分（GPS）和步态变量评分（GVS）已被提议作为步态质量的衡量指标，并已在脑瘫儿童中得到验证。本研究的目的是通过评估丘脑底核深部脑刺激和左旋多巴对步态的影响，将这种验证扩展到帕金森病患者。16名参与者在接受刺激、药物治疗或两者联合治疗时对其步态进行了评估。统一帕金森病评定量表（UPDRS）显示出与先前研究一致的统计学显著差异。GPS和GDI显示出相似的治疗效果，髋关节和膝关节屈伸的GVS也是如此，用Cohen's d评估时为中度或高度。总体而言，结果表明这些步态指标对该组患者的治疗敏感，并且它们在脑瘫儿童以外的群体中的应用是有效的。
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