Hoffmann L, Putzke H P, Bendel L, Erdmann T, Huckstorf C
Urological Clinic, Wilhelm-Pieck-University of Rostock, German Democratic Republic.
J Cancer Res Clin Oncol. 1988;114(3):273-8. doi: 10.1007/BF00405833.
The prostate epithelium of rats which received repeated cadmium chloride (CdCl2) injections showed a gradual disruption of structural differentiation. Electron microscopy studies revealed severe changes in the ultrastructure affecting all epithelial cell organelles, particularly the nuclei, rough endoplasmatic reticulum, the golgi apparatus, and mitochondria. The cells infiltrating the stroma contained secretory vacuoles and their nuclear evaginations on the invasion front showed similarities to ultrastructural pathological changes in man. Examinations of the ventral prostate following oral CdCl2 administration revealed changes ranging in severity up to dysplasia, but there was no evidence of carcinoma.
接受反复氯化镉（CdCl2）注射的大鼠前列腺上皮显示出结构分化的逐渐破坏。电子显微镜研究揭示了超微结构的严重变化，影响所有上皮细胞细胞器，尤其是细胞核、粗面内质网、高尔基体和线粒体。浸润基质的细胞含有分泌泡，其在侵袭前沿的核内陷与人的超微结构病理变化相似。口服CdCl2后对腹侧前列腺的检查显示变化严重程度达发育异常，但无癌变证据。
