镉对大鼠前列腺的致癌作用。
Carcinogenic effects of cadmium on the prostate of the rat.
作者信息
Hoffmann L, Putzke H P, Kampehl H J, Russbült R, Gase P, Simonn C, Erdmann T, Huckstorf C
出版信息
J Cancer Res Clin Oncol. 1985;109(3):193-9. doi: 10.1007/BF00390356.
Abstract
The carcinogenic effects of cadmium were tested in an animal experiment to check the results of epidemiological studies showing that the incidence of prostatic carcinoma is above average in workers industrially exposed to high cadmium levels. For this purpose 1.9 mg CdCl2 (1.2 mg Cd/kg body weight) was injected into the right ventral prostatic lobe of 12-month-old male inbred rats of the Okamoto-toki strain. Simple hyperplasia was found in 38, atypical hyperplasia in 29, atypical hyperplasia with severe dysplasia in 11 and invasive prostatic carcinoma in 5 of 100 animals 270 days after the injection. Various mechanisms are discussed in connection with the carcinogenic action of cadmium.
摘要
在一项动物实验中测试了镉的致癌作用，以检验流行病学研究结果，该结果表明，在工业上接触高镉水平的工人中，前列腺癌的发病率高于平均水平。为此，将1.9毫克氯化镉（1.2毫克镉/千克体重）注入冈本时 strain 12个月大的雄性近交大鼠的右腹侧前列腺叶。注射后270天，在100只动物中，38只出现单纯性增生，29只出现非典型增生，11只出现伴有严重发育异常的非典型增生，5只出现浸润性前列腺癌。讨论了与镉致癌作用相关的各种机制。
相似文献
1
Carcinogenic effects of cadmium on the prostate of the rat.镉对大鼠前列腺的致癌作用。
J Cancer Res Clin Oncol. 1985;109(3):193-9. doi: 10.1007/BF00390356.
2
Electron microscopic results on the ventral prostate of the rat after CdCl2 administration. A contribution towards etiology of the cancer of the prostate.氯化镉给药后大鼠腹侧前列腺的电子显微镜检查结果。对前列腺癌病因学的一项贡献。
J Cancer Res Clin Oncol. 1988;114(3):273-8. doi: 10.1007/BF00405833.
3
The tumor-inhibiting effect of diethylstilbestrol and its diphosphate on the Nb-H and Nb-R prostatic carcinomas of the rat.己烯雌酚及其二磷酸盐对大鼠Nb - H和Nb - R前列腺癌的抑瘤作用。
J Cancer Res Clin Oncol. 1990;116(2):159-67. doi: 10.1007/BF01612671.
4
Chemopreventive effects of zinc on prostate carcinogenesis induced by N-methyl-N-nitrosourea and testosterone in adult male Sprague-Dawley rats.锌对 N-甲基-N-亚硝脲和睾酮诱导的成年雄性 Sprague-Dawley 大鼠前列腺癌发生的化学预防作用。
J Cancer Res Clin Oncol. 2011 Apr;137(4):677-86. doi: 10.1007/s00432-010-0926-4. Epub 2010 Jun 16.
5
Cadmium, lung and prostate cancer: a systematic review of recent epidemiological data.
J Toxicol Environ Health B Crit Rev. 2003 May-Jun;6(3):227-55. doi: 10.1080/10937400306465.
6
Chronic toxic and carcinogenic effects of oral cadmium in the Noble (NBL/Cr) rat: induction of neoplastic and proliferative lesions of the adrenal, kidney, prostate, and testes.口服镉对诺布尔（NBL/Cr）大鼠的慢性毒性和致癌作用：诱发肾上腺、肾脏、前列腺和睾丸的肿瘤性和增殖性病变。
J Toxicol Environ Health A. 1999 Oct 29;58(4):199-214. doi: 10.1080/009841099157296.
7
Portulaca oleracea Extract Ameliorates Testosterone Propionate-Induced Benign Prostatic Hyperplasia in Male Sprague-Dawley Rats.马齿苋提取物改善丙酸睾酮诱导的雄性Sprague-Dawley大鼠良性前列腺增生。
Vet Med Sci. 2025 Jan;11(1):e70184. doi: 10.1002/vms3.70184.
8
Protective Effects of Niclosamide Ethanolamine Against Testosterone-Induced Benign Prostatic Hyperplasia in Rats.氯硝柳胺乙醇胺对睾酮诱导的大鼠良性前列腺增生的保护作用
Drug Res (Stuttg). 2025 Jul;75(6):225-234. doi: 10.1055/a-2576-4153. Epub 2025 Apr 28.
9
Protective effect of mannose oligosaccharides on cadmium-induced hepatic oxidative damage in rats.甘露寡糖对镉诱导的大鼠肝脏氧化损伤的保护作用。
Pol J Vet Sci. 2025 Jun;28(2):311-320. doi: 10.24425/pjvs.2025.154952.
10
Time-course physiological and transcriptomic study reveals cadmium effects on antioxidant, apoptosis, and immunity in the kidney of the freshwater snail Pomacea canaliculata.时间进程生理和转录组学研究揭示镉对淡水螺福寿螺肾脏中抗氧化、凋亡和免疫的影响。
Environ Pollut. 2025 Sep 15;381:126601. doi: 10.1016/j.envpol.2025.126601. Epub 2025 Jun 3.
引用本文的文献
1
Histopathological changes associated with exposure to metal welding fumes in some organs of in Kano, Nigeria.尼日利亚卡诺州部分器官中与接触金属焊接烟尘相关的组织病理学变化。
Toxicol Rep. 2021 Feb 25;8:422-428. doi: 10.1016/j.toxrep.2021.02.016. eCollection 2021.
2
Enhancing effect of cadmium on rat ventral prostate carcinogenesis induced by 3,2'-dimethyl-4-aminobiphenyl.镉对3,2'-二甲基-4-氨基联苯诱导的大鼠腹侧前列腺癌发生的增强作用。
Jpn J Cancer Res. 1993 Oct;84(10):1023-30. doi: 10.1111/j.1349-7006.1993.tb02796.x.
3
Zinc, cadmium and selenium concentrations in separated epithelium and stroma from prostatic tissues of different histology.
Urol Res. 1987;15(3):161-3. doi: 10.1007/BF00254429.
4
Oncogenicity of rat prostate cells transformed in vitro with cadmium chloride.用氯化镉体外转化的大鼠前列腺细胞的致癌性。
Arch Toxicol. 1988;61(6):450-6. doi: 10.1007/BF00293691.
5
Electron microscopic results on the ventral prostate of the rat after CdCl2 administration. A contribution towards etiology of the cancer of the prostate.氯化镉给药后大鼠腹侧前列腺的电子显微镜检查结果。对前列腺癌病因学的一项贡献。
J Cancer Res Clin Oncol. 1988;114(3):273-8. doi: 10.1007/BF00405833.
6
Cancer risk from inorganics.无机物质导致的癌症风险。
Cancer Metastasis Rev. 1987;6(2):113-54. doi: 10.1007/BF00052846.
7
Epidemiological and experimental aspects of metal carcinogenesis: physicochemical properties, kinetics, and the active species.金属致癌作用的流行病学和实验研究：物理化学性质、动力学及活性物种
Environ Health Perspect. 1991 Nov;95:157-89. doi: 10.1289/ehp.9195157.
本文引用的文献
1
2
CADMIUM PROTEINURIA--THE HEALTH OF BATTERY WORKERS EXPOSED TO CADMIUM OXIDE DUST.镉蛋白尿——接触氧化镉粉尘的电池工人的健康状况
Ann Occup Hyg. 1965 Mar;8:55-61. doi: 10.1093/annhyg/8.1.55.
3
CADMIUM NEOPLASIA: TESTICULAR ATROPHY AND LEYDIG CELL HYPERPLASIA AND NEOPLASIA IN RATS AND MICE FOLLOWING THE SUBCUTANEOUS INJECTION OF CADMIUM SALTS.镉致瘤：大鼠和小鼠皮下注射镉盐后出现睾丸萎缩、莱迪希细胞增生及肿瘤形成
Br J Cancer. 1964 Dec;18(4):674-81. doi: 10.1038/bjc.1964.77.
4
CADMIUM NEOPLASIA: SARCOMATA AT THE SITE OF INJECTION OF CADMIUM SULPHATE IN RATS AND MICE.镉致瘤：硫酸镉注射部位大鼠和小鼠发生的肉瘤
Br J Cancer. 1964 Dec;18(4):667-73. doi: 10.1038/bjc.1964.76.
5
CHROMIUM, LEAD, CADMIUM, NICKEL AND TITANIUM IN MICE: EFFECT ON MORTALITY, TUMORS AND TISSUE LEVELS.小鼠体内的铬、铅、镉、镍和钛：对死亡率、肿瘤及组织水平的影响。
J Nutr. 1964 Jul;83:239-50. doi: 10.1093/jn/83.3.239.
6
SPECIFICITY OF ZINC PATHWAY THROUGH THE BODY: HOMEOSTATIC CONSIDERATIONS.锌在体内代谢途径的特异性：稳态考量
Am J Physiol. 1964 Apr;206:787-92. doi: 10.1152/ajplegacy.1964.206.4.787.
7
EFFECT OF ZINC ON CANCEROGENESIS BY CADMIUM.锌对镉致癌作用的影响。
Proc Soc Exp Biol Med. 1964 Mar;115:653-7. doi: 10.3181/00379727-115-28996.
8
COMMENTS ON ZINC IN THE HUMAN AND CANINE PROSTATES.关于人类和犬类前列腺中锌的评论
Natl Cancer Inst Monogr. 1963 Oct;12:337-40.
9
CADMIUM-INDUCED INTERSTITIAL CELL TUMORS IN RATS AND MICE AND THEIR PREVENTION BY ZINC.镉诱导大鼠和小鼠间质细胞瘤及其锌预防作用
J Natl Cancer Inst. 1963 Oct;31:745-59.
10
Cadmium as a carcinogen.镉作为一种致癌物。
Nature. 1962 Feb 10;193:592-3. doi: 10.1038/193592a0.
Zotero 插件