Anderstam B, Harms-Ringdahl M
Department of Radiobiology, University of Stockholm, Sweden.
Int J Hyperthermia. 1988 May-Jun;4(3):297-306. doi: 10.3109/02656738809051105.
We have earlier shown that glutathione depletion, achieved by BSO administration, only marginally increases the antineoplastic activity of hyperthermic or bleomycin treatments in C3H mammary adenocarcinoma, grown subcutaneously in the hind paw of CBA mice. In this study we evaluated the role of glutathione depletion on the antineoplastic activity of combined hyperthermic and bleomycin treatments on the same tumour model system. The activity was recorded by determination of tumour volumes 12 days after treatment and by tumour regression frequencies. When hyperthermic and bleomycin treatments were combined, their respective effects on the 12-day volume values were additive, irrespective of treatment sequence and presence of BSO. However, BSO increased significantly the tumour regression frequencies accomplished by combined hyperthermic and bleomycin treatments, particularly of hyperthermic treatments given together with or 24 h after bleomycin. It is not possible to conclude, at present, whether this effect is caused by low glutathione levels.
我们之前已经表明，通过给予丁硫氨酸亚砜胺（BSO）实现的谷胱甘肽耗竭，仅略微增加了在CBA小鼠后爪皮下生长的C3H乳腺腺癌中热疗或博来霉素治疗的抗肿瘤活性。在本研究中，我们评估了谷胱甘肽耗竭对同一肿瘤模型系统中热疗和博来霉素联合治疗的抗肿瘤活性的作用。通过在治疗后12天测定肿瘤体积和肿瘤消退频率来记录活性。当热疗和博来霉素联合治疗时，无论治疗顺序和BSO的存在与否，它们对12天体积值的各自影响是相加的。然而，BSO显著增加了热疗和博来霉素联合治疗所实现的肿瘤消退频率，特别是与博来霉素一起或在博来霉素给药后24小时给予的热疗。目前尚无法得出该效应是否由低谷胱甘肽水平引起的结论。
