卵巢性激素对雌性大鼠非甾体抗炎药所致胃损伤的影响。
Effect of ovarian sex hormones on non-steroidal anti-inflammatory drug-induced gastric lesions in female rats.
作者信息
Sangma Tultul K, Jain Seema, Mediratta Pramod K
机构信息
Department of Pharmacology, University College of Medical Sciences and Gugu Teg Bahadur Hospital, New Delhi, India.
出版信息
Indian J Pharmacol. 2014 Jan-Feb;46(1):113-6. doi: 10.4103/0253-7613.125191.
OBJECTIVE
The objective of the following study is to investigate the effect of ovarian sex hormones on gastric ulcer in female rats.
MATERIALS AND METHODS
Female rats were treated daily with estrogen (0.05 and 0.1 mg/kg), progesterone (2.0 and 5.0 mg/kg), combined estrogen (0.05 mg/kg) and progesterone (2.0 mg/kg), ranitidine (30 mg/kg) or vehicle for 7 days. Ulcers were induced with aspirin on 7th day. Four hours later, animals were sacrificed and stomach were removed for macroscopic and biochemical examination.
RESULTS
Estrogen in 0.05 and 0.1 doses showed 32% and 18% of ulcer inhibition, respectively, progesterone 09% and 14% inhibition in 2.0 and 5.0 mg/kg doses, respectively, whereas combined estrogen and progesterone showed 23% and ranitidine showed 60% inhibition. However, the inhibition attained and the stomach malondialdehyde and glutathione levels in sex hormone treated groups were not statistically significant when compared to control group.
CONCLUSION
At the tested doses, these ovarian sex hormones neither worsen nor protect against aspirin-induced gastric lesions in female rats.
目的
以下研究的目的是调查卵巢性激素对雌性大鼠胃溃疡的影响。
材料与方法
雌性大鼠每日接受雌激素（0.05和0.1毫克/千克）、孕酮（2.0和5.0毫克/千克）、联合雌激素（0.05毫克/千克）和孕酮（2.0毫克/千克）、雷尼替丁（30毫克/千克）或赋形剂治疗7天。在第7天用阿司匹林诱导溃疡。4小时后，处死动物并取出胃进行宏观和生化检查。
结果
0.05和0.1剂量的雌激素分别显示出32%和18%的溃疡抑制率，2.0和5.0毫克/千克剂量的孕酮分别显示出9%和14%的抑制率，而联合雌激素和孕酮显示出23%的抑制率，雷尼替丁显示出60%的抑制率。然而，与对照组相比，性激素治疗组达到的抑制率以及胃丙二醛和谷胱甘肽水平无统计学意义。
结论
在测试剂量下，这些卵巢性激素既不会加重也不会预防雌性大鼠阿司匹林诱导的胃损伤。
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