Cappuccio F P, Markandu N D, MacGregor G A
Department of Medicine, Charing Cross & Westminster Medical School, London, England.
J Cardiovasc Pharmacol. 1987;10 Suppl 10:S57-61.
The acute blood pressure lowering effect of nifedipine as a capsule was enhanced by a high-sodium intake in both normotensive and hypertensive subjects. In a double-blind, randomised, placebo-controlled study, the longer-term effect of nifedipine as a tablet in hypertensives was also greater on a high sodium intake than on a normal or low sodium diet. In hypertensive patients who were already on regular treatment with nifedipine, the addition of a thiazide diuretic for 1 month did not cause any significant additional fall in blood pressure despite untoward metabolic side effects. These findings, therefore, strengthen the view that there is a link between the blood pressure lowering activity of calcium entry antagonists and the state of sodium balance.
硝苯地平胶囊的急性降压作用在正常血压和高血压受试者中均因高钠摄入而增强。在一项双盲、随机、安慰剂对照研究中，硝苯地平片剂对高血压患者的长期作用在高钠摄入时也比正常或低钠饮食时更大。在已经接受硝苯地平常规治疗的高血压患者中，加用噻嗪类利尿剂1个月尽管有不良代谢副作用，但并未导致血压进一步显著下降。因此，这些发现强化了钙通道拮抗剂的降压活性与钠平衡状态之间存在联系的观点。
