Unger T, Demmert G, Rohmeiss P, Veelken R, Luft F C
German Institute for High Blood Pressure Research, Heidelberg, F.R.G.
J Cardiovasc Pharmacol. 1987;10 Suppl 12:S221-4.
We tested the baroreflex in conscious, stroke-prone spontaneously hypertensive rats (SHRSP) and normotensive Wistar-Kyoto controls (WKY) with incremental bolus injections of nitroprusside and methoxamine. The change in heart rate (HR) per change in mean blood pressure (MAP) was greater in WKY than in SHRSP. In contrast, the change in splanchnic nerve activity (SpNA) per change in MAP was greater in SHRSP than in WKY. The sympathetic outflow in SHRSP seems more reactive to blood pressure changes than in WKY. The discordance in HR and SpNA changes suggests that the integration of autonomic function in SHRSP is impaired.
我们通过递增推注硝普钠和甲氧明，对清醒的易中风自发性高血压大鼠（SHRSP）和正常血压的Wistar-Kyoto对照大鼠（WKY）的压力反射进行了测试。WKY中平均动脉压（MAP）每变化一次时心率（HR）的变化幅度大于SHRSP。相反，SHRSP中MAP每变化一次时内脏神经活动（SpNA）的变化幅度大于WKY。与WKY相比，SHRSP中的交感神经流出似乎对血压变化更具反应性。HR和SpNA变化的不一致表明SHRSP中自主神经功能的整合受损。
