自体纤维蛋白组织粘合剂：影响粘合力的因素
Autologous fibrin tissue adhesive: factors influencing bonding power.
作者信息
Siedentop K H, Harris D M, Sanchez B
机构信息
Department of Otolaryngology-Head and Neck Surgery, University of Illinois College of Medicine, Chicago 60612.
出版信息
Laryngoscope. 1988 Jul;98(7):731-3. doi: 10.1288/00005537-198807000-00008.
Bonding power of Autologous Fibrin Tissue Adhesive (AFTA) is directly related to its fibrinogen concentration. By increasing the ammonium sulfate concentration 100% during fibrinogen precipitation, the bonding power of two glued 1-cm2 pieces of human dura almost doubled. No relationship between blood fibrinogen level and bonding power was demonstrated. Comparing AFTA with Fibrin Sealant, the commercial fibrin tissue adhesive, shearing strength between two glued pieces of human dura with AFTA was less 10 minutes and greater 30 minutes after gluing. Gluing a TORP (Richards) to a 1-cm2 piece of human dura yielded generally somewhat greater bonding power when using Fibrin Sealant. Autologous Fibrin Tissue Adhesive provides bonding power adequate for middle-ear surgery, eliminates transmission of viral diseases and, unlike Fibrin Sealant, AFTA is available in the United States.
自体纤维蛋白组织粘合剂（AFTA）的粘结力与其纤维蛋白原浓度直接相关。在纤维蛋白原沉淀过程中将硫酸铵浓度提高100%，两块粘贴在一起的1平方厘米人硬脑膜的粘结力几乎增加了一倍。未证明血液纤维蛋白原水平与粘结力之间存在关联。将AFTA与商业纤维蛋白组织粘合剂纤维蛋白封闭剂进行比较，使用AFTA粘贴两块人硬脑膜后的剪切强度在粘贴后10分钟时较低，30分钟时较高。在将一枚人工听骨（理查兹公司产品）粘贴到1平方厘米人硬脑膜上时，使用纤维蛋白封闭剂通常能产生略大的粘结力。自体纤维蛋白组织粘合剂提供了足以用于中耳手术的粘结力，消除了病毒性疾病的传播，并且与纤维蛋白封闭剂不同，AFTA在美国可以获得。
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