Department of Chemistry, Graduate School of Science, Kyoto University , Sakyo, Kyoto 606-8502, Japan.
Org Lett. 2014 Mar 7;16(5):1530-2. doi: 10.1021/ol5000742. Epub 2014 Feb 19.
The highly regio- and enantioselective hydroxyamination of aldehydes with in situ generated nitrosocarbonyl compounds from a hydroxamic acid derivative was realized by simple and readily available chiral amine catalysts. The resulting hydroxyamination products were readily converted to the corresponding chiral 1,2-aminoalcohol or allylamine derivatives in one pot.
手性胺催化剂可实现由羟肟酸衍生物原位生成的亚硝酰基化合物对醛的高区域和对映选择性羟胺化反应。所得羟胺化产物可在一锅反应中很容易转化为相应的手性 1,2-氨基醇或烯丙胺衍生物。
