Sundström E, Archer T, Melander T, Hökfelt T
Department of Histology and Neurobiology, Karolinska Institute, Stockholm, Sweden.
Neurosci Lett. 1988 Jun 7;88(3):331-5. doi: 10.1016/0304-3940(88)90233-9.
The effect of intraventricular administration of the neuropeptide galanin on acquisition and retrieval in a modified Morris swim maze was studied in rats. Galanin induced a significant deficit in the acquisition of the task while no effects on the retrieval were observed. No deficits were seen 24 h after the last treatment. Galanin did not increase the number of failures to reach the platform. It is suggested that endogenous galanin modulates learning possibly via the galanin-containing cholinergic neurons in the septum-basal forebrain area projecting to the hippocampus and cortex.
