在一名眼皮肤白化病患者中，通过影像学评估发现转移性基底细胞癌的独特病例观察。
Observation of a unique case of metastatic basal cell carcinoma found by radiographic evaluation in a patient with oculocutaneous albinism.
作者信息
Johnston Mickaila, Winham Whitney, Massoll Nicole, Gardner Jerad M
机构信息
Division of Nuclear Medicine, University of Arkansas for Medical Sciences, Little Rock, AR, 72205, USA ; Current address: Naval Medical Center San Diego, CA, USA.
Department of Pathology, University of Arkansas for Medical Sciences, Little Rock, AR, 72205, USA.
出版信息
F1000Res. 2014 Jan 15;3:10. doi: 10.12688/f1000research.3-10.v1. eCollection 2014.
BACKGROUND
Basal cell carcinoma is one of the more common cancers worldwide; 2.8 million are diagnosed annually in the USA. However, the rate at which it metastasizes is considered very low, between 0.0028 and 0.5%. For those rare cases in which metastases occur, approximately one third metastasize to the lung.
CASE
Presented is a 62-year-old Caucasian male with oculocutaneous albinism and a history of basal cell carcinomas occurring in multiple anatomic sites, most recently at the bilateral forearm and back. Surveillance PET/CT imaging led to the discovery of no less than 30 lung nodules which were consistent with basal cell carcinoma on biopsy. Histological features were remarkably similar in both the primary tumor and in the metastases.
CONCLUSION
An unusual case of a non-head and neck primary basal cell carcinoma metastatic to the lung was discovered on surveillance PET/CT imaging, in a patient with oculocutaneous albinism.
背景
基底细胞癌是全球较为常见的癌症之一；在美国，每年有280万人被诊断出患有该病。然而，其转移率被认为非常低，在0.0028%至0.5%之间。对于那些发生转移的罕见病例，约三分之一会转移至肺部。
病例
本文报告一名62岁患有眼皮肤白化病的白种男性，其多个解剖部位曾发生基底细胞癌，最近一次出现在双侧前臂和背部。监测性PET/CT成像发现不少于30个肺结节，活检显示这些结节与基底细胞癌相符。原发性肿瘤和转移灶的组织学特征非常相似。
结论
在一名患有眼皮肤白化病的患者中，通过监测性PET/CT成像发现了一例罕见的非头颈部原发性基底细胞癌转移至肺部的病例。
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