Ihn H, Nakamura K, Abe M, Furue M, Takehara K, Nakagawa H, Ishibashi Y
Department of Dermatology, Faculty of Medicine, University of Tokyo, Japan.
J Am Acad Dermatol. 1993 May;28(5 Pt 2):895-900. doi: 10.1016/0190-9622(93)70128-g.
Melanomas are rare in patients who have albinism, compared with the frequent occurrence of squamous cell carcinomas and basal cell carcinomas. This report describes amelanotic metastatic melanoma in a 58-year-old Japanese man who had tyrosinase-positive oculocutaneous albinism. A prolonged bleeding time, facioscapulohumeral muscular dystrophy, and Gilbert syndrome were also present. Superficial spreading melanoma with evidence of spontaneous regression on his right forearm was suspected as a possible primary site. Twenty-two cases of melanomas in persons who have albinism have been reported.
与鳞状细胞癌和基底细胞癌的高发性相比，黑色素瘤在白化病患者中较为罕见。本报告描述了一名58岁酪氨酸酶阳性的眼皮肤白化病日本男性患者的无色素性转移性黑色素瘤。该患者还存在出血时间延长、面肩肱型肌营养不良和吉尔伯特综合征。其右前臂疑似为浅表扩散性黑色素瘤且有自发消退迹象，可能是原发部位。此前已报道过22例白化病患者患黑色素瘤的病例。
