Department of Epidemiology and Statistics, School of Public Health, Anhui Medical University, No. 81 Meishan road, Hefei, Anhui 230032, China.
Prog Neuropsychopharmacol Biol Psychiatry. 2013 Oct 1;46:78-85. doi: 10.1016/j.pnpbp.2013.06.015. Epub 2013 Jul 4.
Previous studies concerning the association between the 5,10-methylenetetrahydrofolate reductase (MTHFR) C677T gene polymorphism and depression have provided inconclusive findings. A meta-analysis was therefore performed to investigate a more reliable estimate.
This meta-analysis recruited 26 published studies which were selected by a search of electronic databases up to January 2013, including 4992 depression cases and 17,082 controls. Odds ratios (ORs) with 95% confidence intervals (CIs) were used to assess the association between MTHFR C677T polymorphism and depression susceptibility using random effect models.
Meta-analyses results suggested that MTHFR C677T polymorphism contributed to the increased depression risk in overall populations (for T vs. C: OR=1.19, 95%CI=1.07-1.32; for TT+CT vs. CC: OR=1.15, 95%CI=1.01-1.31; for TT vs. CC: OR=1.42, 95%CI=1.16-1.75; for TT vs. CT+CC: OR=1.38, 95%CI=1.16-1.63). Subgroup analysis by ethnicity indicated an association in Asian populations (for T vs. C: OR=1.36, 95%CI=1.11-1.66; for TT+CT vs. CC: OR=1.32, 95%CI=1.03-1.69; for TT vs. CC: OR=1.88, 95%CI=1.26-2.79; for TT vs. CT+CC: OR=1.76, 95%CI=1.30-2.38); and a marginal association in White populations (for TT vs. CT+CC: OR=1.15, 95%CI=1.01-1.31). However, the association between the MTHFR C677T polymorphism and depression was not observed in the elderly.
The MTHFR C677T polymorphism was associated with an increased risk of depression, especially in Asian populations. However, there was no evidence indicating a correlation in the elderly.
之前关于 5,10-亚甲基四氢叶酸还原酶（MTHFR）C677T 基因多态性与抑郁症之间关联的研究得出的结论并不一致。因此，进行了一项荟萃分析以得出更可靠的结论。
本荟萃分析共纳入了 26 项已发表的研究，这些研究通过检索电子数据库至 2013 年 1 月进行筛选，包括 4992 例抑郁症病例和 17082 例对照。使用随机效应模型，用比值比（OR）及其 95%置信区间（CI）来评估 MTHFR C677T 多态性与抑郁症易感性之间的关联。
荟萃分析结果表明，MTHFR C677T 多态性与总体人群的抑郁症发病风险增加有关（T 等位基因与 C 等位基因相比：OR=1.19，95%CI=1.07-1.32；TT+CT 基因型与 CC 基因型相比：OR=1.15，95%CI=1.01-1.31；TT 基因型与 CC 基因型相比：OR=1.42，95%CI=1.16-1.75；TT 基因型与 CT+CC 基因型相比：OR=1.38，95%CI=1.16-1.63）。按种族亚组分析显示，这种关联仅存在于亚洲人群（T 等位基因与 C 等位基因相比：OR=1.36，95%CI=1.11-1.66；TT+CT 基因型与 CC 基因型相比：OR=1.32，95%CI=1.03-1.69；TT 基因型与 CC 基因型相比：OR=1.88，95%CI=1.26-2.79；TT 基因型与 CT+CC 基因型相比：OR=1.76，95%CI=1.30-2.38）；而在白种人群中则仅为边缘性关联（TT 基因型与 CT+CC 基因型相比：OR=1.15，95%CI=1.01-1.31）。然而，MTHFR C677T 多态性与老年人的抑郁症之间没有观察到相关性。
MTHFR C677T 多态性与抑郁症的发病风险增加相关，尤其是在亚洲人群中。然而，在老年人中没有证据表明存在相关性。
