Davies P F, Olesen S P, Clapham D E, Morrel E M, Schoen F J
Department of Pathology, Brigham and Women's Hospital, Boston, MA 02115.
Hypertension. 1988 Jun;11(6 Pt 2):563-72. doi: 10.1161/01.hyp.11.6.563.a.
By virtue of its location at the interface of flowing blood and vascular tissue, the endothelial cell monolayer is in a unique position for interactions with soluble and cellular elements of the blood on one side and with component cells of the vascular tissue on the other. This brief review outlines humoral and contact-mediated endothelial communication with other cells, particularly the resident cells of the vessel wall. Evidence for gap junctional communication channels between endothelium and vascular cells is summarized and discussed in relation to endothelial ion channel activity. Myoendothelial gap junctional communication is proposed as a mechanism involved in vasorelaxation, either independent of or in concert with secreted endothelium-derived relaxing factor(s).
由于内皮细胞单层位于流动血液与血管组织的界面处，它处于独特的位置，一方面可与血液中的可溶性成分和细胞成分相互作用，另一方面可与血管组织的组成细胞相互作用。本简要综述概述了内皮细胞与其他细胞（尤其是血管壁驻留细胞）之间的体液介导和接触介导的通讯。总结并讨论了内皮细胞与血管细胞之间间隙连接通讯通道的证据，并将其与内皮离子通道活性相关联。提出肌内皮间隙连接通讯是一种参与血管舒张的机制，其独立于或与分泌的内皮衍生舒张因子协同发挥作用。
