Tennekoon Kamani H, Poopalapillai Jayanthiny, Karunanayake Akila G, Jayasinghe Hasini D, Kumarasiri Jayalath M, De S Wijesundera Ajita P, Karunanayake Eric H
Institute of Biochemistry, Molecular Biology and Biotechnology, University of Colombo, Colombo, Sri Lanka.
Horm Res Paediatr. 2014;81(4):232-8. doi: 10.1159/000356919. Epub 2014 Feb 19.
Leptin and insulin-like growth factor-I (IGF-I) promote fetal growth. Their availability is modulated by soluble leptin receptor (SLR) and insulin-like growth factor-binding proteins (IGFBP). Studies that accounted for SLR levels when investigating the association of leptin, IGF-I and IGFBPs on birth indices are scarce.
Cord blood leptin, SLR, IGF-I, IGFBP-1 and their association with birth indices were studied in term newborns (n = 110; males = 60). Data were compared between males and females using the Mann-Whitney U test/unpaired Student's t test as appropriate. Univariate correlations and multiple regression analyses were performed to identify variables significantly influencing birth indices.
Birth indices were comparable between male and female newborns. Females had a significantly lower SLR (p = 0.0142), a higher leptin/Ponderal index (p = 0.033) and a higher free leptin index (leptin/SLR) (p = 0.0081). Leptin and male gender positively and IGFBP-1 negatively influenced birth weight (p = 0.0005, p = 0.02, and p = 0.005, respectively) and head circumference (p = 0.0052, p = 0.0098, and p = 0.0183, respectively) when accounted for other variables. When tested in a different multiple regression model, the free leptin index positively influenced crown-heel length (p = 0.0016) in addition to birth weight (p < 0.0001) and head circumference (p = 0.0016).
In healthy full-term pregnancies, cord blood leptin and IGFBP-1 exert independent and opposing effects on fetal growth.
瘦素和胰岛素样生长因子-I（IGF-I）促进胎儿生长。它们的可利用性受可溶性瘦素受体（SLR）和胰岛素样生长因子结合蛋白（IGFBP）调节。在研究瘦素、IGF-I和IGFBP与出生指标的关联时，考虑SLR水平的研究较少。
对足月儿（n = 110；男性 = 60）的脐血瘦素、SLR、IGF-I、IGFBP-1及其与出生指标的关联进行了研究。根据情况，使用曼-惠特尼U检验/非配对学生t检验对男性和女性的数据进行比较。进行单变量相关性和多元回归分析，以确定对出生指标有显著影响的变量。
男、女新生儿的出生指标相当。女性的SLR显著较低（p = 0.0142），瘦素/体重指数较高（p = 0.033），游离瘦素指数（瘦素/SLR）较高（p = 0.0081）。在考虑其他变量时，瘦素和男性性别对出生体重（分别为p = 0.0005、p = 0.02和p = 0.005）和头围（分别为p = 0.0052、p = 0.0098和p = 0.0183）有正向影响，而IGFBP-1有负向影响。在不同的多元回归模型中进行测试时，游离瘦素指数除了对出生体重（p < 0.0001）和头围（p = 0.0016）有正向影响外，还对顶臀长有正向影响（p = 0.0016）。
在健康的足月妊娠中，脐血瘦素和IGFBP-1对胎儿生长发挥独立且相反的作用。
