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新疆维吾尔族人群中GNB3基因多态性与原发性高血压的关联性研究

Association study on GNB3 gene polymorphism with essential hypertension in Xinjiang Uygur group.

作者信息

Jing Jianying, Wang Dan, Jiao Yi, Wang Xiaofeng, Wen Hao, Lin Renyong, Jin Jianzhong, Jin Li

机构信息

Department of Biology, School of Environment and Chemical Engineering, Luoyang University, Luoyang, 471000, China,

出版信息

Front Med China. 2007 May;1(2):230-3. doi: 10.1007/s11684-007-0045-z.

Abstract

The relationship between the tenth exon C825T of G-protein β3 subunit (GNB3) genetic polymorphism and hypertension in the Uygur population of China was investigated. A nested case-control study (n = 738) was carried out. Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) technique was used to genotype GNB3 C825T polymorphism in 354 hypertensive (HT) and 384 normotensive (NT) Uygur subjects. The distributions of GNB3 C825T genotypes were CC (27.2%), TT (42.9%), and CT (29.9%) in the hypertensive subjects and CC (27.7%), TT (42.4%), CT (29.9%) in the normotensive subjects. There were no significant differences in the genotype distributions between the two groups (χ (2) = 0.0262 P = 0.99). The T allele was 51.4% in hypertensive subjects and 51.2% in normotensive subjects, which, between the two groups, was not a significant difference (χ (2) = 0.0016 P = 0.97). Further analysis shows that there is no association between C825T genotypes and age, body mass index (BMI), Glucose (GLU), Triglyceride (TG), Cholesterol (CHO), systolic blood pressure (SBP) and diastolic blood pressure (DBP). No evidence was found to suggest an association between GNB3 C825T polymorphism and hypertension in the Uygur population of China.

摘要

研究了中国维吾尔族人群中G蛋白β3亚基(GNB3)基因多态性的第10外显子C825T与高血压之间的关系。开展了一项巢式病例对照研究(n = 738)。采用聚合酶链反应-限制性片段长度多态性(PCR-RFLP)技术对354例维吾尔族高血压(HT)患者和384例血压正常(NT)者的GNB3 C825T多态性进行基因分型。高血压患者中GNB3 C825T基因型的分布为CC(27.2%)、TT(42.9%)和CT(29.9%),血压正常者中CC(27.7%)、TT(42.4%)、CT(29.9%)。两组间基因型分布无显著差异(χ² = 0.0262,P = 0.99)。高血压患者中T等位基因频率为51.4%,血压正常者中为51.2%,两组间无显著差异(χ² = 0.0016,P = 0.97)。进一步分析表明,C825T基因型与年龄、体重指数(BMI)、血糖(GLU)、甘油三酯(TG)、胆固醇(CHO)、收缩压(SBP)和舒张压(DBP)之间无关联。未发现证据表明中国维吾尔族人群中GNB3 C825T多态性与高血压有关联。

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