Department of Neurology, Institute of Surgery Research, Daping Hospital, Third Military Medical University, Yuzhong District, Chongqing, PR China.
PLoS One. 2013 Jun 14;8(6):e65863. doi: 10.1371/journal.pone.0065863. Print 2013.
Several epidemiological studies have evaluated the association between the GNB3 C825T polymorphism and hypertension or stroke. The results of these studies were inconsistent; therefore, we performed a meta-analysis to clarify these discrepancies.
We systematically searched the PubMed, Embase, Web of Science, CNKI, and CBM databases, and manually searched reference lists of relevant papers, meeting abstracts, and relevant journals. Pooled odds ratios (ORs) and 95% confidence intervals (CIs) were calculated for dominant, recessive, and allelic models. A fixed or random effects model was separately adopted depending on study heterogeneity. Subgroup and sensitivity analyses were performed to detect study heterogeneity and examine result stability, respectively. Publication bias was tested using funnel plots, the Egger's regression test, and Begg's test.
We screened 66 studies regarding hypertension and eight concerning stroke. A combined analysis showed that only the allelic model found a marginal association with hypertension (OR = 1.07, 95% CI = 1.01-1.13) and female gender (OR = 1.11, 95% CI = 0.99-1.24). However, no comparison models found an association with stroke (allelic model: OR = 1.11, 95% CI = 0.94-1.32; dominant model: OR = 1.16, 95% CI = 0.92-1.48; and recessive model: OR = 1.05, 95% CI = 0.97-1.14). Sensitivity analysis suggested that all models did not yield a relationship to hypertension or stroke among Asians. Besides, there was a lack of statistical association with hypertension in Caucasians, which maybe due to a small sample size. When we restricted the included studies to normal populations according to the Hardy-Weinberg equilibrium, no association was found.
There was no evidence indicating that the 825T allele or TT genotype was associated with hypertension or stroke in Asians or hypertension in Caucasians. However, further studies regarding Africans and other ethnicities are needed to identify further correlations.
几项流行病学研究评估了 GNB3 C825T 多态性与高血压或中风之间的关系。这些研究的结果不一致；因此，我们进行了荟萃分析以澄清这些差异。
我们系统地检索了 PubMed、Embase、Web of Science、CNKI 和 CBM 数据库，并手动检索了相关论文的参考文献列表、会议摘要和相关期刊。对于显性、隐性和等位基因模型，计算了合并的优势比（OR）和 95%置信区间（CI）。根据研究异质性，分别采用固定或随机效应模型。进行亚组和敏感性分析，分别检测研究异质性和检验结果稳定性。使用漏斗图、Egger 回归检验和 Begg 检验检测发表偏倚。
我们筛选了 66 项关于高血压的研究和 8 项关于中风的研究。综合分析表明，只有等位基因模型与高血压（OR=1.07，95%CI=1.01-1.13）和女性（OR=1.11，95%CI=0.99-1.24）存在边缘关联。然而，没有比较模型与中风相关（等位基因模型：OR=1.11，95%CI=0.94-1.32；显性模型：OR=1.16，95%CI=0.92-1.48；隐性模型：OR=1.05，95%CI=0.97-1.14）。敏感性分析表明，所有模型在亚洲人群中与高血压或中风均无关联。此外，在高加索人群中，高血压与所有模型均无统计学关联，这可能是由于样本量较小。当我们根据 Hardy-Weinberg 平衡将纳入的研究限制在正常人群中时，没有发现关联。
没有证据表明 825T 等位基因或 TT 基因型与亚洲人群中的高血压或中风或高加索人群中的高血压相关。然而，需要进一步研究非洲人和其他种族以确定进一步的相关性。
