Uebelhart Brigitte, Rizzoli René
Service des maladies osseuses, Département des spécialités de médecine, HUG, 1211 Genève.
Rev Med Suisse. 2014 Jan 15;10(412-413):101-7.
The quality of the management of patients with osteoporosis varies by country. The recommendations of the Swiss Association against osteoporosis propose intervention thresholds based on the results of the FRAX tool. Despite increasing number of observational studies with several hundred thousands of patients, it is not possible to conclude to a clear increased risk of cardiovascular disease with calcium intakes. A persistent effect of zoledronic acid is observed even after one single injection. There is no increased fracture risk within 7 months following Denosumab treatment cessation.
骨质疏松症患者的管理质量因国家而异。瑞士骨质疏松症防治协会的建议基于FRAX工具的结果提出了干预阈值。尽管有涉及数十万患者的观察性研究数量不断增加,但仍无法得出钙摄入量会明显增加心血管疾病风险的结论。即使仅注射一次唑来膦酸,也能观察到其持续效果。在停止使用地诺单抗治疗后的7个月内,骨折风险没有增加。