Enblad P, Busch C, Carlsson U, Ekelund G, Glimelius B, Lindström C, Pontén J, Påhlman L
Department of Surgery, Uppsala University, Akademiska Sjukhuset, Sweden.
Am J Clin Pathol. 1988 Aug;90(2):121-30. doi: 10.1093/ajcp/90.2.121.
The reaction patterns of eight antibodies directed against blood group substances A, B, and H and against Lewis B antigen, difucosylated carbohydrate antigens (DFCA), gastrointestinal cancer antigen (GICA) CA 19-9, carcinoma-associated antigen CA-50, and carcinoembryonic antigen (CEA) were studied in mucosa and adenomas of the rectum. Antigenic heterogeneity was a common feature of rectal mucosa and was observed to a considerable degree in adenomas. In general, the rectal mucosa expressed only a few antigens and to a limited extent. The adenomas were more extensively stained than the rectal mucosa. The proportion of positive cells increased with the grade of dysplasia but was relatively unrelated to the histologic type. The proportion of individual antigens expressed and the number of antigens extensively expressed increased between rectal mucosa, benign adenomas, and adenomas with early invasive carcinoma. These findings support the concept of an adenoma (dysplasia)-carcinoma sequence.
研究了8种针对血型物质A、B、H、Lewis B抗原、二岩藻糖基化碳水化合物抗原（DFCA）、胃肠道癌抗原（GICA）CA 19-9、癌相关抗原CA-50和癌胚抗原（CEA）的抗体在直肠黏膜和腺瘤中的反应模式。抗原异质性是直肠黏膜的一个常见特征，在腺瘤中也有相当程度的观察到。一般来说，直肠黏膜仅表达少数抗原，且程度有限。腺瘤的染色比直肠黏膜更广泛。阳性细胞的比例随发育异常程度增加，但与组织学类型相对无关。在直肠黏膜、良性腺瘤和早期浸润癌的腺瘤之间，表达的单个抗原比例和广泛表达的抗原数量增加。这些发现支持腺瘤（发育异常）-癌序列的概念。
