Barad D H, Ryan K J, Elkind-Hirsch K, Makris A
Laboratory of Human Reproduction and Reproductive Biology, Harvard Medical School, Boston, Massachusetts.
Am J Obstet Gynecol. 1988 Jul;159(1):242-6. doi: 10.1016/0002-9378(88)90529-7.
Although substance P has been demonstrated in the nonhuman ovary, it has not previously been identified in normal human ovarian tissue. We examined ovarian surgical specimens from 30 women for the presence of immunoreactive substance P. With the use of a specific radioimmunoassay, immunoreactive substance P was identified in these ovarian extracts. The geometric mean of the immunoreactive substance P concentration was 0.55 pg/mg wet weight (95% confidence limits 0.04 and 6.15). Thecal and stromal concentrations of immunoreactive substance P were greater than those in the corpora lutea and tunica albuginea. Large follicles had a lower concentration of immunoreactive substance P than did small follicles. We conclude that the neuropeptide substance P is present in some normal human ovaries and may be a modulator of ovarian function.
尽管P物质已在非人类卵巢中得到证实，但此前尚未在正常人类卵巢组织中被鉴定出来。我们检查了30名女性的卵巢手术标本中免疫反应性P物质的存在情况。通过使用特定的放射免疫测定法，在这些卵巢提取物中鉴定出了免疫反应性P物质。免疫反应性P物质浓度的几何平均值为0.55 pg/mg湿重（95%置信区间为0.04和6.15）。免疫反应性P物质在卵泡膜和基质中的浓度高于黄体和白膜中的浓度。大卵泡中免疫反应性P物质的浓度低于小卵泡。我们得出结论，神经肽P物质存在于一些正常人类卵巢中，可能是卵巢功能的调节因子。
