Tuite Mick F, Howard Mark J, Xue Wei-Feng
Kent Fungal Group, School of Biosciences, University of Kent, Canterbury, Kent CT2 7NJ, UK.
Protein Science Group, School of Biosciences, University of Kent, Canterbury, Kent CT2 7NJ, UK.
Chem Biol. 2014 Feb 20;21(2):172-3. doi: 10.1016/j.chembiol.2014.02.001.
Prion proteins can be propagated as amyloid fibrils with several different conformational variants. By providing structural information at atomic level for two such variants of a yeast prion, Frederick and colleagues, in this issue of Chemistry & Biology, reveal how conformational flexibility can generate phenotypic diversity.
