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早期药物流产后的简化随访:电话随访及自行进行低灵敏度尿妊娠试验的12个月经验

Simplified follow-up after early medical abortion: 12-month experience of a telephone call and self-performed low-sensitivity urine pregnancy test.

作者信息

Michie Lucy, Cameron Sharon T

机构信息

Department of Reproductive and Developmental Sciences, University of Edinburgh, 51 Little France Crescent, Edinburgh, EH16 5SU, United Kingdom; Simpson Centre for Reproductive Health, Royal Infirmary of Edinburgh, 51 Little France Crescent, Edinburgh, EH16 4SA, United Kingdom.

Department of Reproductive and Developmental Sciences, University of Edinburgh, 51 Little France Crescent, Edinburgh, EH16 5SU, United Kingdom; Simpson Centre for Reproductive Health, Royal Infirmary of Edinburgh, 51 Little France Crescent, Edinburgh, EH16 4SA, United Kingdom.

出版信息

Contraception. 2014 May;89(5):440-5. doi: 10.1016/j.contraception.2014.01.010. Epub 2014 Jan 21.

Abstract

OBJECTIVE

The objective was to determine if simplified follow-up after early medical abortion, consisting of a telephone call 2 weeks after the procedure plus a self-performed low-sensitivity urine pregnancy (LSUP) test, was successful for screening for ongoing pregnancies in the year following its introduction as standard service.

STUDY DESIGN

A retrospective computerized database review of 1084 women at a hospital abortion service in Edinburgh, UK, who had a medical abortion (≤9 weeks) and went home to expel the pregnancy was performed. Women who screened 'positive' at telephone follow-up on the basis of ongoing pregnancy symptoms, scant bleeding or LSUP test result were scheduled for an ultrasound. The main outcome measures were the proportion of women scheduled for telephone follow-up successfully contacted and the proportion of ongoing pregnancies detected.

RESULTS

A total of 943 women were scheduled for telephone follow-up. Ten women presented to the hospital before the time of the follow-up call. Of the remaining 933 women, 656 [70%, 95% confidence interval (CI) 67.7-73.2] were successfully contacted. Five hundred seventy-three (87%, 95% CI 84.5-89.7) of those contacted screened 'negative'; no false negatives occurred. Eighty-three (13%, 95% CI 10.2-15.5) screened 'positive,' and of those, three had ongoing pregnancies. Of the 277 (30%, 95% CI 26.7-32.7) who were not contacted, two ongoing pregnancies occurred. The sensitivity of telephone follow-up with LSUP to detect ongoing pregnancy was 100% (95% CI 30.9%-100%), and specificity was 88% (95% CI 84.9%-90.1%). The negative predictive value was 100% (95% CI 99.1%-100%), and positive predictive value was 3.6% (95% CI 0.9%-10.9%).

CONCLUSION

A telephone call and LSUP test at 2 weeks are suitable as a standard method of follow-up for screening for ongoing pregnancy after early medical abortion.

IMPLICATIONS STATEMENT

For most women, a routine clinic follow-up after early medical abortion (to exclude ongoing pregnancy) can be replaced with a telephone call and a self-performed LSUP test at 2 weeks postprocedure.

摘要

目的

确定早期药物流产后的简化随访方式是否成功,该方式包括术后2周的电话随访以及自行进行的低灵敏度尿液妊娠试验(LSUP),并将其作为标准服务推出后的一年里用于筛查持续性妊娠。

研究设计

对英国爱丁堡一家医院流产服务中心的1084名进行药物流产(妊娠≤9周)并回家自行排出妊娠物的女性进行回顾性计算机数据库审查。根据持续妊娠症状、少量出血或LSUP检测结果在电话随访中筛查为“阳性”的女性安排超声检查。主要观察指标为成功联系到的安排电话随访的女性比例以及检测到的持续性妊娠比例。

结果

共有943名女性被安排电话随访。10名女性在随访电话时间之前前来医院。其余933名女性中,656名(70%,95%置信区间[CI]67.7 - 73.2)成功联系上。其中573名(87%,95%CI84.5 - 89.7)筛查为“阴性”;未出现假阴性。83名(13%,95%CI10.2 - 15.5)筛查为“阳性”,其中3名有持续性妊娠。在未联系到的277名(30%,95%CI26.7 - 32.7)女性中,有2名出现持续性妊娠。电话随访结合LSUP检测持续性妊娠的灵敏度为100%(95%CI30.9% - 100%),特异度为88%(95%CI84.9% - 90.1%)。阴性预测值为100%(95%CI99.1% - 100%),阳性预测值为3.6%(95%CI0.9% - 10.9%)。

结论

术后2周的电话随访和LSUP检测适合作为早期药物流产后筛查持续性妊娠的标准随访方法。

意义声明

对于大多数女性,早期药物流产后的常规门诊随访(以排除持续性妊娠)可以用术后2周的电话随访和自行进行的LSUP检测来替代。

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