婴儿 7 价肺炎球菌结合疫苗免疫改变过敏性气道疾病小鼠模型中年轻成年人 CD4(+)T 细胞亚群。
Infant 7-valent pneumococcal conjugate vaccine immunization alters young adulthood CD4(+)T cell subsets in allergic airway disease mouse model.
机构信息
Ministry of Education, Key Laboratory of Child Development and Disorders, Key Laboratory of Pediatrics in Chongqing, Chongqing International Science and Technology Cooperation Center for Child Development and Disorders, Chongqing, China.
Ministry of Education, Key Laboratory of Child Development and Disorders, Key Laboratory of Pediatrics in Chongqing, Chongqing International Science and Technology Cooperation Center for Child Development and Disorders, Chongqing, China; Ultrasound division, Children's Hospital, Chongqing Medical University, Chongqing, China.
出版信息
Vaccine. 2014 Apr 11;32(18):2079-85. doi: 10.1016/j.vaccine.2014.02.013. Epub 2014 Feb 21.
7-Valent pneumococcal conjugate vaccine (PCV7) immunization in adulthood can inhibit allergic asthma in mouse model. The aim of this study is to investigate the effects of infant PCV7 immunization on young adulthood CD4(+)T cell subsets in a murine allergic airway disease (AAD) model. Our study indicated that infant PCV7 immunization can inhibit young adulthood airway inflammation and airway hyperresponsiveness (AHR) by inducing the production of Foxp3(+)Treg, Th1 cells and their cytokines IL-10 and IFN-γ, inhibiting the production of Th2, Th17 cells and their cytokines IL-13 and IL-17A in BALB/c mice model. These results suggested that infant PCV7 immunization may serve as an effective measure to prevent young adulthood mice AAD.
7 价肺炎球菌结合疫苗（PCV7）在成年期的免疫接种可以抑制小鼠模型中的过敏性哮喘。本研究旨在探讨婴儿 PCV7 免疫接种对过敏性气道疾病（AAD）模型中小鼠成年早期 CD4+T 细胞亚群的影响。我们的研究表明，婴儿 PCV7 免疫接种可以通过诱导 Foxp3+Treg、Th1 细胞及其细胞因子 IL-10 和 IFN-γ的产生，抑制 Th2、Th17 细胞及其细胞因子 IL-13 和 IL-17A 的产生，来抑制 BALB/c 小鼠模型中的年轻成年期气道炎症和气道高反应性（AHR）。这些结果表明，婴儿 PCV7 免疫接种可能是预防年轻成年期小鼠 AAD 的有效措施。
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