将核与细胞骨架连接起来，以实现核定位和细胞迁移。
Connecting the nucleus to the cytoskeleton for nuclear positioning and cell migration.
机构信息
INSERM UMR S 787-Groupe Myologie, Faculté de Médecine - Pitié-Salpêtrière, Université Pierre et Marie Curie, 105 boulevard de l'Hôpital, 75634, Paris, Cedex 13, France,
出版信息
Adv Exp Med Biol. 2014;773:505-20. doi: 10.1007/978-1-4899-8032-8_23.
The position of the nucleus in the cytoplasm is a highly regulated process and is required for multiple cellular and developmental processes. Defects on different nuclear positioning events are associated with several pathologies such as muscle and nervous system disorders. In this chapter we describe the current knowledge on the mechanism of nuclear positioning. We discuss how the nucleus connects to the cytoskeleton by nesprins and SUN proteins, how this connection is regulated by Samp1, and how this connection is required for proper nuclear positioning. Furthermore, we discuss how nesprins, SUN, and Samp1 form transmembrane actin-associated nuclear (TAN) lines, novel nuclear envelope structures involved in force transduction during nuclear movement. Finally, we describe the recent evidences suggesting a role for the connection between the nucleus and the cytoskeleton in cancer.
核在细胞质中的位置是一个高度调节的过程，对多种细胞和发育过程都是必需的。不同的核定位事件的缺陷与多种病理有关，如肌肉和神经系统疾病。在本章中，我们描述了核定位的机制的最新知识。我们讨论了核是如何通过 nesprins 和 SUN 蛋白与细胞骨架相连的，这种连接是如何被 Samp1 调节的，以及这种连接对于正确的核定位是如何必需的。此外，我们还讨论了 nesprins、SUN 和 Samp1 如何形成跨膜肌动蛋白相关核（TAN）线，这是一种新型的核膜结构，参与核运动过程中的力传递。最后，我们描述了最近的证据表明，核与细胞骨架之间的连接在癌症中起作用。
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