Fang M-Y, Wang S-Y, Zheng Y-B, Gong L-Y, Bao W-L, Gu D-L, Mao W-M
Department of Integrated Chinese Traditional Medicine and Western Medicine, Zhejiang Cancer Hospital, Zhejiang Thoracic Oncology Institute, Zhejiang Cancer Center, Banshanqiao District, Hangzhou, People's Republic of China.
Eur Rev Med Pharmacol Sci. 2014;18(3):398-403.
Scatter factor, also known as hepatocyte growth factor (SF/HGF), is a polypeptide growth factor with a number of biologic activities, including cell scattering, stimulation of cell motility, mitogenesis, morphogenesis, angiogenesis, and cellular invasiveness, it is thought to be important in the growth and spread of several carcinomas. We assessed whether preoperative plasma levels of HGF and carcinoembryonic antigen (CEA) can enhance the accuracy of standard models for predicting pathologic features and clinical outcomes.
The study comprised 45 consecutive patients treated with surgery for clinically localized non-small-cell lung cancer. HGF and CEA were measured using the commercially available immunoassay. Multivariate logistic regression was used to assess the relationship between plasma HGF/CEA and pathologic features. Multivariate Cox regression was used to predict disease recurrence.
Patients with lung squamous cell cancer (SCC) more frequently had higher plasma HGF, whereas CEA levels were significantly elevated in patients with non-SCC histology. Preoperative plasma HGF and CEA levels were not the independent predictors of overall survival.
Preoperative plasma levels of HGF and CEA are not the independent predictors of non-small lung cancer disease recurrence and metastasis after surgery; HGF is a predictor of lung squamous cell cancer. Use of HGF may help in therapeutic decision-making and estimate the histological type of NSCLC.
分散因子，也称为肝细胞生长因子（SF/HGF），是一种具有多种生物学活性的多肽生长因子，包括细胞分散、刺激细胞运动、促有丝分裂、形态发生、血管生成和细胞侵袭，它被认为在几种癌症的生长和扩散中起重要作用。我们评估了术前血浆中HGF和癌胚抗原（CEA）水平是否能提高预测病理特征和临床结果的标准模型的准确性。
本研究包括45例连续接受手术治疗的临床局限性非小细胞肺癌患者。使用市售免疫测定法测量HGF和CEA。多变量逻辑回归用于评估血浆HGF/CEA与病理特征之间的关系。多变量Cox回归用于预测疾病复发。
肺鳞状细胞癌（SCC）患者血浆HGF水平较高的情况更为常见，而非SCC组织学类型的患者CEA水平显著升高。术前血浆HGF和CEA水平不是总生存的独立预测因素。
术前血浆HGF和CEA水平不是非小细胞肺癌术后疾病复发和转移的独立预测因素；HGF是肺鳞状细胞癌的预测因素。HGF的应用可能有助于治疗决策并估计非小细胞肺癌的组织学类型。
