Lai Han, Xiao Yijie, Yan Shengyong, Tian Fangfang, Zhong Cheng, Liu Yi, Weng Xiaocheng, Zhou Xiang
Analyst. 2014 Apr 21;139(8):1834-8. doi: 10.1039/c3an02269b.
In this study, we present a fluorescent switch-on probe based on a cyanovinyl-pyridinium triphenylamine (CPT) derivative that exhibited a 190-fold increase in fluorescence upon binding to G-quadruplex-forming oligonucleotide 22AG. This probe showed specificity and selectivity towards an antiparallel G-quadruplex, indicating its promising potential in G-quadruplex imaging.
在本研究中，我们展示了一种基于氰基乙烯基吡啶三苯胺（CPT）衍生物的荧光开启探针，该探针在与形成G-四链体的寡核苷酸22AG结合后荧光增强了190倍。该探针对反平行G-四链体具有特异性和选择性，表明其在G-四链体成像方面具有广阔的应用前景。
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