Zgaljardic Dennis J, Durham William J, Mossberg Kurt A, Foreman Jack, Joshipura Keta, Masel Brent E, Urban Randall, Sheffield-Moore Melinda
Transitional Learning Center , Galveston, TX , USA and.
Brain Inj. 2014;28(4):389-97. doi: 10.3109/02699052.2014.884242. Epub 2014 Feb 24.
Fatigue is a common and debilitating phenomenon experienced by individuals with traumatic brain injury (TBI) that can negatively influence rate and extent of functional recovery by reducing participation in brain injury rehabilitation services and increasing maladaptive lifestyle practices. The underlying mechanisms of TBI-related fatigue are not entirely understood and focused research on symptom reduction or prevention is limited.
The current review of the literature suggests that the aetiology of TBI-related fatigue can be viewed as a multifactorial and complex model impacting physiological systems (i.e. endocrine, skeletal muscle and cardiorespiratory) that can be directly or indirectly influenced by neuropsychological correlates including cognitive and psychological impairment. Distinguishing central from peripheral fatigue is helpful in this regard. Potential therapeutic strategies and pharmacological agents to help alleviate fatigue in this patient population are discussed.
疲劳是创伤性脑损伤（TBI）患者常见且使人衰弱的现象，它会通过减少参与脑损伤康复服务以及增加适应不良的生活方式而对功能恢复的速度和程度产生负面影响。TBI相关疲劳的潜在机制尚未完全明确，针对症状减轻或预防的重点研究有限。
当前的文献综述表明，TBI相关疲劳的病因可被视为一个多因素的复杂模型，它影响生理系统（即内分泌、骨骼肌和心肺系统），而这些生理系统会直接或间接受神经心理学相关因素影响，包括认知和心理损伤。在这方面，区分中枢性疲劳和外周性疲劳是有帮助的。本文还讨论了有助于减轻该患者群体疲劳的潜在治疗策略和药物。
