海藻酸损伤会减少纹状体多巴胺受体和1,4 - 二氢吡啶位点。

Kainic acid lesions decrease striatal dopamine receptors and 1,4-dihydropyridine sites.

作者信息

Skattebøl A, Hruska R E, Hawthorn M, Triggle D J

机构信息

Department of Biochemical Pharmacology, School of Pharmacy, State University of New York, Buffalo 14260.

出版信息

Neurosci Lett. 1988 Jun 17;89(1):85-9. doi: 10.1016/0304-3940(88)90485-5.

DOI:10.1016/0304-3940(88)90485-5

PMID:2456499

Abstract

The effects of intrastriatal injection of kainic acid (2 microliters, 1 mg/ml) in the rat were determined. Four weeks after the lesioning, striatal dopamine receptors and 1,4-dihydropyridine sites were measured by radioligand binding with [3H]spiperone and [3H]nimodipine, respectively. Dopamine receptor and 1,4-dihydropyridine binding densities were decreased by 58% and 43% respectively, with no change in binding affinity for either ligand. 1,4-Dihydropyridine-sensitive Ca2+ channels may be located primarily on postsynaptic elements.

摘要

测定了向大鼠脑内纹状体注射海人藻酸（2微升，1毫克/毫升）的效果。损伤四周后，分别通过用[3H]司哌罗宁和[3H]尼莫地平进行放射性配体结合实验来测定纹状体多巴胺受体和1,4-二氢吡啶位点。多巴胺受体和1,4-二氢吡啶结合密度分别降低了58%和43%，而两种配体的结合亲和力均无变化。1,4-二氢吡啶敏感的Ca2+通道可能主要位于突触后元件上。