Northwestern University, Chicago, Ill.
J Allergy Clin Immunol Pract. 2013 Sep-Oct;1(5):541-2. doi: 10.1016/j.jaip.2013.04.010. Epub 2013 Aug 6.
The study by Van Zele et al reports positive results for a randomized, double-blind, placebo-controlled trial that used either 20 days of doxycycline (200 mg the first day, followed by 100 mg daily) or 20 days of a tapering schedule of methyl prednisolone (32 mg on days 1-5, 16 mg on days 6-10, and 8 mg on days 11-20) for the treatment of nasal polyps. The primary end point was reduction in nasal polyp score which was graded 0 to 4 on each side, resulting in a score range of 0 to 8; the score was determined at baseline and weeks 1, 2, 4, 8, and 12. Entry criteria required that the patient either have recurrent polyps after surgery or massive polyps (grade 3 or 4); the total polyp score in each of the 3 groups averaged approximately 6. The patient population in this study was therefore at the severe end of the spectrum; results may not be generalizable to patients with milder disease.
范泽尔等人的研究报告了一项随机、双盲、安慰剂对照试验的阳性结果，该试验使用了 20 天的强力霉素（第 1 天 200 毫克，然后每天 100 毫克）或 20 天的甲基强的松龙递减方案（第 1-5 天 32 毫克，第 6-10 天 16 毫克，第 11-20 天 8 毫克）治疗鼻息肉。主要终点是鼻息肉评分的降低，每侧评分为 0 至 4 分，总分为 0 至 8 分；评分在基线和第 1、2、4、8 和 12 周确定。入选标准要求患者要么在手术后有复发性息肉，要么有大量息肉（3 级或 4 级）；每组的总息肉评分平均约为 6。因此，这项研究中的患者人群处于疾病严重程度的极端；结果可能不适用于病情较轻的患者。
