Raffel C, Boggan J E, Eng L F, Davis R L, Wilson C B
Department of Neurological Surgery, School of Medicine, University of California, San Francisco.
Surg Neurol. 1988 Aug;30(2):125-30. doi: 10.1016/0090-3019(88)90097-3.
Pituitary adenomas from 15 patients with Cushing's disease were studied histopathologically. The tumors were examined for the presence of neural axons by the Bodian silver impregnation technique and a specific immunohistologic technique based on a monoclonal antibody to axonal neurofilaments. Axons were not seen in any of the surgical specimens. This finding suggests that most, if not all, adrenocorticotropin-secreting pituitary adenomas are of anterior lobe origin.
对15例库欣病患者的垂体腺瘤进行了组织病理学研究。采用博迪安银浸染技术以及基于抗轴突神经丝单克隆抗体的特异性免疫组织学技术，检测肿瘤中神经轴突的存在情况。在任何手术标本中均未发现轴突。这一发现表明，大多数（即便不是全部）分泌促肾上腺皮质激素的垂体腺瘤起源于前叶。
