Küppers Verena, Vockel Matthias, Nottebaum Astrid F, Vestweber Dietmar
Max Planck Institute for Molecular Biomedicine, Röntgenstr. 20, 48149, Münster, Germany.
Cell Tissue Res. 2014 Mar;355(3):577-86. doi: 10.1007/s00441-014-1812-1. Epub 2014 Feb 25.
The endothelial layer of blood vessels controls the passage of cells and solutes from the blood into the surrounding tissue. Crucial for this regulation is the integrity of endothelial cell-cell junctions. Various molecular mechanisms control junctional integrity of the endothelial layer including GTPases, modulation of the actomyosin cytoskeleton and phosphorylation and dephosphorylation of junctional proteins. Several kinases and phosphatases have been identified that are good candidates for the regulation of the endothelial barrier function. For some of them, in vivo evidence has recently been presented that highlights their importance in either the regulation of vascular permeability or leukocyte extravasation. This review will summarize current knowledge about the regulation of endothelial junctions by kinases and phosphatases. In particular, the role of the endothelial specific phosphatase VE-PTP in the context of endothelial cell contact stability will be highlighted.
血管的内皮细胞层控制着细胞和溶质从血液进入周围组织的过程。内皮细胞间连接的完整性对于这种调节至关重要。多种分子机制控制着内皮细胞层的连接完整性，包括小GTP酶、肌动球蛋白细胞骨架的调节以及连接蛋白的磷酸化和去磷酸化。已经鉴定出几种激酶和磷酸酶，它们是调节内皮屏障功能的良好候选者。对于其中一些，最近已有体内证据表明它们在调节血管通透性或白细胞外渗方面具有重要作用。本综述将总结关于激酶和磷酸酶调节内皮连接的当前知识。特别是，将突出内皮特异性磷酸酶VE-PTP在内皮细胞接触稳定性方面的作用。
